Zoledronic acid administration failed to prevent bone loss at the knee in persons with acute spinal cord injury: an observational cohort study
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0602-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0602-x | ||
| 245 | 0 | 0 | |a Zoledronic acid administration failed to prevent bone loss at the knee in persons with acute spinal cord injury: an observational cohort study |h [Elektronische Daten] |c [William Bauman, Christopher Cirnigliaro, Michael La Fountaine, LeighAnn Martinez, Steven Kirshblum, Ann Spungen] |
| 520 | 3 | |a After acute spinal cord injury (SCI), rapid depletion of the sublesional skeleton occurs, particularly at the distal femur and proximal tibia. Subsequently, fragility fractures of the knee may occur. We determined the efficacy of zoledronic acid to prevent sublesional bone mineral density (BMD) loss at 6 and 12months after acute SCI. Thirteen subjects with acute motor-complete SCI were prospectively studied: 6 patients received zoledronic acid (5mg) and 7 subjects did not receive the drug (controls). Zoledronic acid was administered intravenously within 16weeks of acute injury. Areal BMD was performed by dual energy X-ray absorptiometry at baseline, 6, and 12months after administration of drug. The treatment group demonstrated sparing of BMD at the total hip at month 6 (p<0.0006) and at month 12 (p<0.01). In contrast to the findings at the hip, the treatment group had a greater loss of BMD compared to the control group at the distal femur and proximal tibia at month 6 (−7.9%±3.4 vs.−2.7%±5.0, respectively, p=0.054; and −10.5%±6.4 vs. −4.8%±6.8, respectively, p=NS) and at month 12 (−18.5%±3.9 vs. −8.4%±7.2, respectively, p=0.01; and −20.4%±8.8 vs.−7.9%±12.3, respectively, p=0.06). A single dose of zoledronic acid administered soon after acute SCI reduced the %BMD loss at the hip, but appeared to have no effect to prevent %BMD loss at the knee, the site where fracture risk is greatest in persons with SCI. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan (outside the USA), 2014 | ||
| 690 | 7 | |a Spinal cord injury |2 nationallicence | |
| 690 | 7 | |a Zoledronate |2 nationallicence | |
| 690 | 7 | |a Bisphosphonates |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Knee |2 nationallicence | |
| 700 | 1 | |a Bauman |D William |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | |
| 700 | 1 | |a Cirnigliaro |D Christopher |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | |
| 700 | 1 | |a La Fountaine |D Michael |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | |
| 700 | 1 | |a Martinez |D LeighAnn |u Kessler Institute for Rehabilitation, West Orange, NJ, USA |4 aut | |
| 700 | 1 | |a Kirshblum |D Steven |u Kessler Institute for Rehabilitation, West Orange, NJ, USA |4 aut | |
| 700 | 1 | |a Spungen |D Ann |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/4(2015-07-01), 410-421 |x 0914-8779 |q 33:4<410 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0602-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0602-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bauman |D William |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cirnigliaro |D Christopher |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a La Fountaine |D Michael |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Martinez |D LeighAnn |u Kessler Institute for Rehabilitation, West Orange, NJ, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kirshblum |D Steven |u Kessler Institute for Rehabilitation, West Orange, NJ, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Spungen |D Ann |u VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/4(2015-07-01), 410-421 |x 0914-8779 |q 33:4<410 |1 2015 |2 33 |o 774 | ||