caa a22 4500 60546328X CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00774-014-0602-x doi (NATIONALLICENCE)springer-10.1007/s00774-014-0602-x Zoledronic acid administration failed to prevent bone loss at the knee in persons with acute spinal cord injury: an observational cohort study [Elektronische Daten] [William Bauman, Christopher Cirnigliaro, Michael La Fountaine, LeighAnn Martinez, Steven Kirshblum, Ann Spungen] After acute spinal cord injury (SCI), rapid depletion of the sublesional skeleton occurs, particularly at the distal femur and proximal tibia. Subsequently, fragility fractures of the knee may occur. We determined the efficacy of zoledronic acid to prevent sublesional bone mineral density (BMD) loss at 6 and 12months after acute SCI. Thirteen subjects with acute motor-complete SCI were prospectively studied: 6 patients received zoledronic acid (5mg) and 7 subjects did not receive the drug (controls). Zoledronic acid was administered intravenously within 16weeks of acute injury. Areal BMD was performed by dual energy X-ray absorptiometry at baseline, 6, and 12months after administration of drug. The treatment group demonstrated sparing of BMD at the total hip at month 6 (p<0.0006) and at month 12 (p<0.01). In contrast to the findings at the hip, the treatment group had a greater loss of BMD compared to the control group at the distal femur and proximal tibia at month 6 (−7.9%±3.4 vs.−2.7%±5.0, respectively, p=0.054; and −10.5%±6.4 vs. −4.8%±6.8, respectively, p=NS) and at month 12 (−18.5%±3.9 vs. −8.4%±7.2, respectively, p=0.01; and −20.4%±8.8 vs.−7.9%±12.3, respectively, p=0.06). A single dose of zoledronic acid administered soon after acute SCI reduced the %BMD loss at the hip, but appeared to have no effect to prevent %BMD loss at the knee, the site where fracture risk is greatest in persons with SCI. The Japanese Society for Bone and Mineral Research and Springer Japan (outside the USA), 2014 Spinal cord injury nationallicence Zoledronate nationallicence Bisphosphonates nationallicence Osteoporosis nationallicence Knee nationallicence Bauman William VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut Cirnigliaro Christopher VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut La Fountaine Michael VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut Martinez LeighAnn Kessler Institute for Rehabilitation, West Orange, NJ, USA aut Kirshblum Steven Kessler Institute for Rehabilitation, West Orange, NJ, USA aut Spungen Ann VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 410-421 0914-8779 33:4<410 2015 33 774 https://doi.org/10.1007/s00774-014-0602-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0602-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bauman William VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 700 1- Cirnigliaro Christopher VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 700 1- La Fountaine Michael VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 700 1- Martinez LeighAnn Kessler Institute for Rehabilitation, West Orange, NJ, USA aut NATIONALLICENCE 700 1- Kirshblum Steven Kessler Institute for Rehabilitation, West Orange, NJ, USA aut NATIONALLICENCE 700 1- Spungen Ann VA RR&D National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 410-421 0914-8779 33:4<410 2015 33 774