caa a22 4500 605463301 CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00774-014-0608-4 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0608-4 Factors that characterize bone health with aging in healthy postmenopausal women [Elektronische Daten] [Shota Ikegami, Shigeharu Uchiyama, Yukio Nakamura, Keijiro Mukaiyama, Hiroki Hirabayashi, Mikio Kamimura, Kiichi Nonaka, Hiroyuki Kato] The exponential increase in the incidence of fragility fractures in older people is attributed to attenuation of both bone strength and neuromuscular function. Decrease in bone mineral density (BMD) does not entirely explain this increase. The objective of this study is to investigate the effect of age on various parameters related to bone health with aging, and to identify combinations of factors that collectively express the bone metabolic state in healthy postmenopausal women. Height, weight, and grip strength were measured in 135 healthy postmenopausal volunteer women. Hip BMD, biomechanical indices derived from quantitative computed tomography (QCT), cross-sectional areas of muscle and fat of the proximal thigh, and various biochemical markers of bone metabolism were measured. A smaller group of factors explanatory for bone health was identified using factor analysis and each was newly named. As a result, the factors bone mass, bone turnover, bone structure, and muscle strength had the greatest explanatory power for assessing the bone health of healthy postmenopausal women. Whereas dual X-ray absorptiometry parameters only loaded on the factor bone mass, QCT parameters loaded on both the factors bone mass and bone structure. Most bone turnover markers loaded on the factor bone turnover, but deoxypyridinoline loaded on both bone turnover and muscle strength. Age was negatively correlated with bone mass (r=−0.49, p<0.001) and muscle strength (r=−0.67, p<0.001). We conclude that aging is associated as much with muscle weakening as with low BMD. More attention should be paid to the effects of muscle weakening during aging in assessments of bone health. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Bone turnover markers nationallicence Quantitative computed tomography nationallicence Postmenopausal women nationallicence Muscle strength nationallicence Sarcopenia nationallicence Ikegami Shota Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut Uchiyama Shigeharu Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut Nakamura Yukio Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut Mukaiyama Keijiro Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut Hirabayashi Hiroki Department of Orthopaedic Surgery, Marunouchi Hospital, Matsumoto, Japan aut Kamimura Mikio Center for Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic, Matsumoto, Japan aut Nonaka Kiichi Canon Lifecare Solutions Inc., Tokyo, Japan aut Kato Hiroyuki Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 440-447 0914-8779 33:4<440 2015 33 774 https://doi.org/10.1007/s00774-014-0608-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0608-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ikegami Shota Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Uchiyama Shigeharu Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Nakamura Yukio Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Mukaiyama Keijiro Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Hirabayashi Hiroki Department of Orthopaedic Surgery, Marunouchi Hospital, Matsumoto, Japan aut NATIONALLICENCE 700 1- Kamimura Mikio Center for Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic, Matsumoto, Japan aut NATIONALLICENCE 700 1- Nonaka Kiichi Canon Lifecare Solutions Inc., Tokyo, Japan aut NATIONALLICENCE 700 1- Kato Hiroyuki Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 440-447 0914-8779 33:4<440 2015 33 774