caa a22 4500 605463328 CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00774-014-0609-3 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0609-3 Efficacy and safety of odanacatib treatment for patients with osteoporosis: a meta-analysis [Elektronische Daten] [Shi Feng, Zhicheng Luo, Da Liu] The aim of this study was to evaluate the efficacy and safety of odanacatib (ODN) for the treatment of osteoporosis, using data in studies reported in the literature. We performed a literature search to compare the outcomes of applications of once-weekly ODN 50mg and control. The outcomes of osteoporosis evaluated include primary outcome as bone mineral density (BMD) at different skeletal sites, and secondary outcomes, including adverse events (AEs), such as incidence of skin AEs, fracture, and serious adverse events (SAEs). Four trials were included. Mean difference (95% CI) of lumbar spine BMD was 3.41 (1.57-5.24) at 12months and 4.89 (2.72-7.05) at 24months; mean difference (95% CI) of femoral neck BMD was 1.90 (0.73-3.08) at 12months and 3.85 (2.55-5.15) at 24months; mean difference (95% CI) of total hip BMD was 2.65 (1.20-4.09) at 12months and 3.70 (1.76-5.64) at 24months; risk ratio (95% CI) of AEs was 0.98 (0.91-1.07); risk ratio (95% CI) of SAEs was 1.11 (0.72-1.72); risk ratio (95% CI) of skin AEs was 0.92 (0.63-1.35); and risk ratio (95% CI) of fracture was 0.34 (0.16-0.70). In this study, application of 50mg ODN produced significantly greater BMD increases and lower fracture incidence than that of the control. In addition, ODN was generally well tolerated. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Odanacatib nationallicence Bone mineral density nationallicence Safety nationallicence Osteoporosis nationallicence Meta-analysis nationallicence Feng Shi Department of Orthopaedic Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Luo Zhicheng Department of Orthopaedic Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Liu Da Department of Orthopaedic Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 448-454 0914-8779 33:4<448 2015 33 774 https://doi.org/10.1007/s00774-014-0609-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0609-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feng Shi Department of Orthopaedic Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Luo Zhicheng Department of Orthopaedic Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Liu Da Department of Orthopaedic Surgery, Shengjing Hospital, China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 448-454 0914-8779 33:4<448 2015 33 774