Osteoporosis is highly prevalent in Japanese males with chronic obstructive pulmonary disease and is associated with deteriorated pulmonary function
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0605-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0605-7 | ||
| 245 | 0 | 0 | |a Osteoporosis is highly prevalent in Japanese males with chronic obstructive pulmonary disease and is associated with deteriorated pulmonary function |h [Elektronische Daten] |c [Reiko Watanabe, Takeshi Tanaka, Keisuke Aita, Masaaki Hagiya, Toshiaki Homma, Kyoko Yokosuka, Hisami Yamakawa, Tsutomu Yarita, Nobuyuki Tai, Junko Hirano, Daisuke Inoue, Ryo Okazaki] |
| 520 | 3 | |a Osteoporosis has recently been recognized as a major comorbidity in chronic obstructive pulmonary disease (COPD). We conducted a cross-sectional study in a cohort of 136 Japanese males with COPD to evaluate the prevalence of vertebral fracture (VF) and to explore its relationship with pulmonary function parameters. VFs were present in 108 (79.4%); multiple and severe (SQ grade 2 or 3) VFs were found in 77 (56.6%) and 25 (18.4%), respectively. Multivariate logistic regression analyses revealed that decrease in forced expiratory volume in one second (FEV1.0)/forced vital capacity (FVC) [odds ratio (OR) 0.963, 95% confidence interval (CI) 0.929-998, p=0.036] was associated with the presence of VF after adjustment for age and that FVC (OR 0.462, 95% CI 0.220-0.968, p=0.041) and current smoking (OR 2.992, 95% CI 1.128-7.940, p=0.028) were associated with VF severity (grade 2-3 vs. 1). We also found that FEV1.0 was the sole independent determinant of the number of VFs by stepwise multivariate linear regression (p<0.001). Bone mineral density (BMD) values were available in 49 subjects. Mean T scores were −2.0±1.2 in femoral neck, −1.4±1.2 in total hip and −1.1±1.4 in lumbar spine. Nineteen patients (38.8%) had a BMD T score less than −2.5. BMD Z scores of all the sites showed a progressive decrease as GOLD stage of COPD advanced (p<0.05). Our results indicate a high prevalence of osteoporosis in Japanese male COPD patients and a strong inter-relationship between the two diseases, re-emphasizing the urgent need for appropriate intervention to maintain both bone and lung health. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Chronic obstructive pulmonary disease (COPD) |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Vertebral fracture |2 nationallicence | |
| 690 | 7 | |a Bone mineral density |2 nationallicence | |
| 690 | 7 | |a COPD assessment test (CAT) |2 nationallicence | |
| 700 | 1 | |a Watanabe |D Reiko |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Tanaka |D Takeshi |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Aita |D Keisuke |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Hagiya |D Masaaki |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Homma |D Toshiaki |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Yokosuka |D Kyoko |u Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Yamakawa |D Hisami |u Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Yarita |D Tsutomu |u Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Tai |D Nobuyuki |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Hirano |D Junko |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Inoue |D Daisuke |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 700 | 1 | |a Okazaki |D Ryo |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/4(2015-07-01), 392-400 |x 0914-8779 |q 33:4<392 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0605-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0605-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Watanabe |D Reiko |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tanaka |D Takeshi |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aita |D Keisuke |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hagiya |D Masaaki |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Homma |D Toshiaki |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yokosuka |D Kyoko |u Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamakawa |D Hisami |u Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yarita |D Tsutomu |u Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tai |D Nobuyuki |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hirano |D Junko |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Inoue |D Daisuke |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okazaki |D Ryo |u Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/4(2015-07-01), 392-400 |x 0914-8779 |q 33:4<392 |1 2015 |2 33 |o 774 | ||