caa a22 4500 605463344 CHVBK 20210128100253.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00774-014-0605-7 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0605-7 Osteoporosis is highly prevalent in Japanese males with chronic obstructive pulmonary disease and is associated with deteriorated pulmonary function [Elektronische Daten] [Reiko Watanabe, Takeshi Tanaka, Keisuke Aita, Masaaki Hagiya, Toshiaki Homma, Kyoko Yokosuka, Hisami Yamakawa, Tsutomu Yarita, Nobuyuki Tai, Junko Hirano, Daisuke Inoue, Ryo Okazaki] Osteoporosis has recently been recognized as a major comorbidity in chronic obstructive pulmonary disease (COPD). We conducted a cross-sectional study in a cohort of 136 Japanese males with COPD to evaluate the prevalence of vertebral fracture (VF) and to explore its relationship with pulmonary function parameters. VFs were present in 108 (79.4%); multiple and severe (SQ grade 2 or 3) VFs were found in 77 (56.6%) and 25 (18.4%), respectively. Multivariate logistic regression analyses revealed that decrease in forced expiratory volume in one second (FEV1.0)/forced vital capacity (FVC) [odds ratio (OR) 0.963, 95% confidence interval (CI) 0.929-998, p=0.036] was associated with the presence of VF after adjustment for age and that FVC (OR 0.462, 95% CI 0.220-0.968, p=0.041) and current smoking (OR 2.992, 95% CI 1.128-7.940, p=0.028) were associated with VF severity (grade 2-3 vs. 1). We also found that FEV1.0 was the sole independent determinant of the number of VFs by stepwise multivariate linear regression (p<0.001). Bone mineral density (BMD) values were available in 49 subjects. Mean T scores were −2.0±1.2 in femoral neck, −1.4±1.2 in total hip and −1.1±1.4 in lumbar spine. Nineteen patients (38.8%) had a BMD T score less than −2.5. BMD Z scores of all the sites showed a progressive decrease as GOLD stage of COPD advanced (p<0.05). Our results indicate a high prevalence of osteoporosis in Japanese male COPD patients and a strong inter-relationship between the two diseases, re-emphasizing the urgent need for appropriate intervention to maintain both bone and lung health. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Chronic obstructive pulmonary disease (COPD) nationallicence Osteoporosis nationallicence Vertebral fracture nationallicence Bone mineral density nationallicence COPD assessment test (CAT) nationallicence Watanabe Reiko Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Tanaka Takeshi Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Aita Keisuke Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Hagiya Masaaki Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Homma Toshiaki Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Yokosuka Kyoko Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan aut Yamakawa Hisami Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan aut Yarita Tsutomu Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan aut Tai Nobuyuki Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Hirano Junko Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Inoue Daisuke Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Okazaki Ryo Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 392-400 0914-8779 33:4<392 2015 33 774 https://doi.org/10.1007/s00774-014-0605-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0605-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watanabe Reiko Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Tanaka Takeshi Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Aita Keisuke Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Hagiya Masaaki Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Homma Toshiaki Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Yokosuka Kyoko Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Yamakawa Hisami Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Yarita Tsutomu Yarita Hospital, 899 Goi, 299-0056, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Tai Nobuyuki Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Hirano Junko Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Inoue Daisuke Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 700 1- Okazaki Ryo Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 299-0111, Ichihara, Chiba, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 392-400 0914-8779 33:4<392 2015 33 774