caa a22 4500 605463360 CHVBK 20210128100253.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00774-015-0656-4 doi (NATIONALLICENCE)springer-10.1007/s00774-015-0656-4 Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases [Elektronische Daten] [Danielle Callaway, Jean Jiang] Osteoclasts are cells derived from bone marrow macrophages and are important in regulating bone resorption during bone homeostasis. Understanding what drives osteoclast differentiation and activity is important when studying diseases characterized by heightened bone resorption relative to formation, such as osteoporosis. In the last decade, studies have indicated that reactive oxygen species (ROS), including superoxide and hydrogen peroxide, are crucial components that regulate the differentiation process of osteoclasts. However, there are still many unanswered questions that remain. This review will examine the mechanisms by which ROS can be produced in osteoclasts as well as how it may affect osteoclast differentiation and activity through its actions on osteoclastogenesis signaling pathways. In addition, the contribution of ROS to the aging-associated disease of osteoporosis will be addressed and how targeting ROS may lead to the development of novel therapeutic treatment options. The Japanese Society for Bone and Mineral Research and Springer Japan, 2015 Osteoclast nationallicence Reactive oxygen species nationallicence Osteoclastogenesis nationallicence Oxidative stress nationallicence Callaway Danielle Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78229-3900, San Antonio, TX, USA aut Jiang Jean Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78229-3900, San Antonio, TX, USA aut Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 359-370 0914-8779 33:4<359 2015 33 774 https://doi.org/10.1007/s00774-015-0656-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-015-0656-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Callaway Danielle Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78229-3900, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Jiang Jean Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78229-3900, San Antonio, TX, USA aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/4(2015-07-01), 359-370 0914-8779 33:4<359 2015 33 774