caa a22 4500 605463395 CHVBK 20210128100253.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00774-014-0614-6 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0614-6 Ultrasonographic evaluation of parathyroid hyperplasia in multiple endocrine neoplasia type 1: Positive correlation between parathyroid volume and circulating parathyroid hormone concentration [Elektronische Daten] [Hiroyuki Tamiya, Megumi Miyakawa, Akira Takeshita, Daishu Miura, Yasuhiro Takeuchi] There are few reports on parathyroid ultrasonography of multiple endocrine neoplasia type 1 (MEN1). This study investigated the ultrasonographic features of parathyroid glands in 10 patients with MEN1 who underwent preoperative neck ultrasonography and parathyroidectomy between 2006 and 2010 at Toranomon Hospital. We retrospectively analyzed clinical features, laboratory and ultrasonographic data, and pathological diagnosis. A total of 38 parathyroid glands were surgically removed (three to five glands from each patient). All removed parathyroids were pathologically diagnosed as hyperplasia. Seven cases (70.0%) had adenomatous thyroid nodules. Twenty-five enlarged parathyroid glands (65.8%) were detected by preoperative ultrasonography with a detection rate of 81.8% (9/11) and 59.3% (16/27) for patients without and with adenomatous nodules, respectively. Total parathyroid gland weight and potentially predictable total parathyroid volume by preoperative ultrasonography were significantly correlated with preoperative serum intact parathyroid hormone (iPTH) concentration (R=0.97, P<0.001 and R=0.96, P<0.001, respectively). The equation used for prediction of the total volume by ultrasonography was 15×iPTH (pg/ml)-1,000 and that for total weight was 20×iPTH (pg/ml)-1,400. Although adenomatous nodules often coexisted with MEN1 and made identification of enlarged parathyroid glands by ultrasonography difficult, the positive correlation between the predictable parathyroid volume by ultrasonography and serum iPTH suggests that their measurement is useful in the preoperative detection and localization of enlarged parathyroid glands in patients with MEN1. Furthermore, the presence of parathyroid glands that should be resected can be predicted before surgery using the equation proposed here. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Ultrasonography nationallicence Parathyroid hyperplasia nationallicence Parathyroid volume nationallicence MEN1 nationallicence Tamiya Hiroyuki Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Miyakawa Megumi Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Takeshita Akira Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Miura Daishu Division of Breast and Endocrine Surgery, Toranomon Hospital, Tokyo, Japan aut Takeuchi Yasuhiro Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 523-529 0914-8779 33:5<523 2015 33 774 https://doi.org/10.1007/s00774-014-0614-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0614-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tamiya Hiroyuki Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Miyakawa Megumi Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Takeshita Akira Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Miura Daishu Division of Breast and Endocrine Surgery, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Takeuchi Yasuhiro Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 523-529 0914-8779 33:5<523 2015 33 774