caa a22 4500 605463433 CHVBK 20210128100253.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00774-015-0698-7 doi (NATIONALLICENCE)springer-10.1007/s00774-015-0698-7 Pathogenesis and diagnostic criteria for rickets and osteomalacia—proposal by an expert panel supported by the Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research, and the Japan Endocrine Society [Elektronische Daten] [Seiji Fukumoto, Keiichi Ozono, Toshimi Michigami, Masanori Minagawa, Ryo Okazaki, Toshitsugu Sugimoto, Yasuhiro Takeuchi, Toshio Matsumoto] Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations have revealed that the causes of rickets and osteomalacia are quite variable. Although these diseases can severely impair the quality of life of affected patients, rickets and osteomalacia can be completely cured or at least respond to treatment when properly diagnosed and treated according to the specific causes. On the other hand, there are no standard criteria to diagnose rickets or osteomalacia nationally and internationally. Therefore, we summarize the definition and pathogenesis of rickets and osteomalacia, and propose diagnostic criteria and a flowchart for the differential diagnosis of various causes of these diseases. We hope that these criteria and the flowchart are clinically useful for the proper diagnosis and management of these diseases. The Japanese Society for Bone and Mineral Research and Springer Japan, 2015 Vitamin D nationallicence Hypophosphatemia nationallicence Hyopcalcemia nationallicence Fibroblast growth factor 23 nationallicence Fukumoto Seiji Fujii Memorial Institute of Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, 770-8503, Tokushima, Japan aut Ozono Keiichi Department of Pediatrics, Osaka University Graduate School of Medicine, 565-0871, Suita, Japan aut Michigami Toshimi Department of Bone and Mineral Research, Research Institute, Osaka Medical Center for Maternal and Child Health, 594-1101, Izumi, Japan aut Minagawa Masanori Department of Endocrinology, Chiba Children's Hospital, 266-0007, Chiba, Japan aut Okazaki Ryo Third Department of Medicine, Teikyo University Chiba Medical Center, 299-0111, Ichihara, Japan aut Sugimoto Toshitsugu Internal Medicine 1, Faculty of Medicine, Shimane University, 693-8501, Izumo, Japan aut Takeuchi Yasuhiro Division of Endocrinology, Toranomon Hospital Endocrine Center, 105-8470, Tokyo, Japan aut Matsumoto Toshio Fujii Memorial Institute of Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, 770-8503, Tokushima, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 467-473 0914-8779 33:5<467 2015 33 774 https://doi.org/10.1007/s00774-015-0698-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-015-0698-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fukumoto Seiji Fujii Memorial Institute of Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, 770-8503, Tokushima, Japan aut NATIONALLICENCE 700 1- Ozono Keiichi Department of Pediatrics, Osaka University Graduate School of Medicine, 565-0871, Suita, Japan aut NATIONALLICENCE 700 1- Michigami Toshimi Department of Bone and Mineral Research, Research Institute, Osaka Medical Center for Maternal and Child Health, 594-1101, Izumi, Japan aut NATIONALLICENCE 700 1- Minagawa Masanori Department of Endocrinology, Chiba Children's Hospital, 266-0007, Chiba, Japan aut NATIONALLICENCE 700 1- Okazaki Ryo Third Department of Medicine, Teikyo University Chiba Medical Center, 299-0111, Ichihara, Japan aut NATIONALLICENCE 700 1- Sugimoto Toshitsugu Internal Medicine 1, Faculty of Medicine, Shimane University, 693-8501, Izumo, Japan aut NATIONALLICENCE 700 1- Takeuchi Yasuhiro Division of Endocrinology, Toranomon Hospital Endocrine Center, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsumoto Toshio Fujii Memorial Institute of Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, 770-8503, Tokushima, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 467-473 0914-8779 33:5<467 2015 33 774