Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0617-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0617-3 | ||
| 245 | 0 | 0 | |a Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide |h [Elektronische Daten] |c [Naohisa Miyakoshi, Toshiaki Aizawa, Satoshi Sasaki, Shigeru Ando, Shigeto Maekawa, Hiroshi Aonuma, Hiroyuki Tsuchie, Hiroshi Sasaki, Yuji Kasukawa, Yoichi Shimada] |
| 520 | 3 | |a Atypical femoral fracture (AFF) often appears with bisphosphonate use. Teriparatide (TPTD) treatment may promote AFF healing, but few controlled or comparative studies have examined the effects of TPTD on healing of bisphosphonate-associated AFF. We retrospectively reviewed the medical records of 45 consecutive AFFs in 34 Japanese patients who had received oral bisphosphonates (alendronate or risedronate) for osteoporosis before AFF and had been followed for≥12months (range, 12-90months). Thirty-seven complete or incomplete AFFs (82%) were treated surgically and eight incomplete AFFs (18%) were treated conservatively. Bisphosphonates were stopped at diagnosis. Based on TPTD use after fracture, AFFs were divided into non-TPTD (n=24) and TPTD (n=21) groups. Time to fracture-healing and frequency of delayed healing or non-union were compared between groups. Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed. In subanalyses for all AFFs treated surgically, mean (±standard deviation) time to fracture healing was significantly better in the TPTD group (5.4±1.5months) than in the non-TPTD group (8.6±4.7months; P=0.012), and the frequency of delayed healing or non-union was significantly lower in the TPTD group than in the non-TPTD group (P=0.014). Subanalyses for surgically treated complete AFFs yielded similar results, but subanalyses for incomplete AFFs treated conservatively showed no significant differences between groups. TPTD treatment appears to significantly shorten the postoperative time to fracture healing and reduce rates of delayed healing or non-union after bisphosphonate-associated AFF. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Bisphosphonate |2 nationallicence | |
| 690 | 7 | |a Bone union |2 nationallicence | |
| 690 | 7 | |a Femoral fracture |2 nationallicence | |
| 690 | 7 | |a Teriparatide |2 nationallicence | |
| 700 | 1 | |a Miyakoshi |D Naohisa |u Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan |4 aut | |
| 700 | 1 | |a Aizawa |D Toshiaki |u Department of Orthopedic Surgery, Northern Akita Municipal Hospital, KitaAkita, Japan |4 aut | |
| 700 | 1 | |a Sasaki |D Satoshi |u Higashinaruse National Health Insurance Clinic, Higashinaruse, Japan |4 aut | |
| 700 | 1 | |a Ando |D Shigeru |u Department of Orthopedic Surgery, Yamamoto-Kumiai General Hospital, Noshiro, Japan |4 aut | |
| 700 | 1 | |a Maekawa |D Shigeto |u Department of Orthopedic Surgery, Ogachi Central Hospital, Yuzawa, Japan |4 aut | |
| 700 | 1 | |a Aonuma |D Hiroshi |u Department of Orthopedic Surgery, Kakunodate General Hospital, Senboku, Japan |4 aut | |
| 700 | 1 | |a Tsuchie |D Hiroyuki |u Department of Orthopedic Surgery, Nakadoori General Hospital, Akita, Japan |4 aut | |
| 700 | 1 | |a Sasaki |D Hiroshi |u Department of Orthopedic Surgery, Akita-Rosai Hospital, Odate, Japan |4 aut | |
| 700 | 1 | |a Kasukawa |D Yuji |u Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan |4 aut | |
| 700 | 1 | |a Shimada |D Yoichi |u Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/5(2015-09-01), 553-559 |x 0914-8779 |q 33:5<553 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0617-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0617-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Miyakoshi |D Naohisa |u Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aizawa |D Toshiaki |u Department of Orthopedic Surgery, Northern Akita Municipal Hospital, KitaAkita, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sasaki |D Satoshi |u Higashinaruse National Health Insurance Clinic, Higashinaruse, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ando |D Shigeru |u Department of Orthopedic Surgery, Yamamoto-Kumiai General Hospital, Noshiro, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maekawa |D Shigeto |u Department of Orthopedic Surgery, Ogachi Central Hospital, Yuzawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aonuma |D Hiroshi |u Department of Orthopedic Surgery, Kakunodate General Hospital, Senboku, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsuchie |D Hiroyuki |u Department of Orthopedic Surgery, Nakadoori General Hospital, Akita, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sasaki |D Hiroshi |u Department of Orthopedic Surgery, Akita-Rosai Hospital, Odate, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kasukawa |D Yuji |u Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shimada |D Yoichi |u Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/5(2015-09-01), 553-559 |x 0914-8779 |q 33:5<553 |1 2015 |2 33 |o 774 | ||