caa a22 4500 605463476 CHVBK 20210128100253.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00774-014-0617-3 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0617-3 Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide [Elektronische Daten] [Naohisa Miyakoshi, Toshiaki Aizawa, Satoshi Sasaki, Shigeru Ando, Shigeto Maekawa, Hiroshi Aonuma, Hiroyuki Tsuchie, Hiroshi Sasaki, Yuji Kasukawa, Yoichi Shimada] Atypical femoral fracture (AFF) often appears with bisphosphonate use. Teriparatide (TPTD) treatment may promote AFF healing, but few controlled or comparative studies have examined the effects of TPTD on healing of bisphosphonate-associated AFF. We retrospectively reviewed the medical records of 45 consecutive AFFs in 34 Japanese patients who had received oral bisphosphonates (alendronate or risedronate) for osteoporosis before AFF and had been followed for≥12months (range, 12-90months). Thirty-seven complete or incomplete AFFs (82%) were treated surgically and eight incomplete AFFs (18%) were treated conservatively. Bisphosphonates were stopped at diagnosis. Based on TPTD use after fracture, AFFs were divided into non-TPTD (n=24) and TPTD (n=21) groups. Time to fracture-healing and frequency of delayed healing or non-union were compared between groups. Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed. In subanalyses for all AFFs treated surgically, mean (±standard deviation) time to fracture healing was significantly better in the TPTD group (5.4±1.5months) than in the non-TPTD group (8.6±4.7months; P=0.012), and the frequency of delayed healing or non-union was significantly lower in the TPTD group than in the non-TPTD group (P=0.014). Subanalyses for surgically treated complete AFFs yielded similar results, but subanalyses for incomplete AFFs treated conservatively showed no significant differences between groups. TPTD treatment appears to significantly shorten the postoperative time to fracture healing and reduce rates of delayed healing or non-union after bisphosphonate-associated AFF. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Bisphosphonate nationallicence Bone union nationallicence Femoral fracture nationallicence Teriparatide nationallicence Miyakoshi Naohisa Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan aut Aizawa Toshiaki Department of Orthopedic Surgery, Northern Akita Municipal Hospital, KitaAkita, Japan aut Sasaki Satoshi Higashinaruse National Health Insurance Clinic, Higashinaruse, Japan aut Ando Shigeru Department of Orthopedic Surgery, Yamamoto-Kumiai General Hospital, Noshiro, Japan aut Maekawa Shigeto Department of Orthopedic Surgery, Ogachi Central Hospital, Yuzawa, Japan aut Aonuma Hiroshi Department of Orthopedic Surgery, Kakunodate General Hospital, Senboku, Japan aut Tsuchie Hiroyuki Department of Orthopedic Surgery, Nakadoori General Hospital, Akita, Japan aut Sasaki Hiroshi Department of Orthopedic Surgery, Akita-Rosai Hospital, Odate, Japan aut Kasukawa Yuji Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan aut Shimada Yoichi Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 553-559 0914-8779 33:5<553 2015 33 774 https://doi.org/10.1007/s00774-014-0617-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0617-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyakoshi Naohisa Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan aut NATIONALLICENCE 700 1- Aizawa Toshiaki Department of Orthopedic Surgery, Northern Akita Municipal Hospital, KitaAkita, Japan aut NATIONALLICENCE 700 1- Sasaki Satoshi Higashinaruse National Health Insurance Clinic, Higashinaruse, Japan aut NATIONALLICENCE 700 1- Ando Shigeru Department of Orthopedic Surgery, Yamamoto-Kumiai General Hospital, Noshiro, Japan aut NATIONALLICENCE 700 1- Maekawa Shigeto Department of Orthopedic Surgery, Ogachi Central Hospital, Yuzawa, Japan aut NATIONALLICENCE 700 1- Aonuma Hiroshi Department of Orthopedic Surgery, Kakunodate General Hospital, Senboku, Japan aut NATIONALLICENCE 700 1- Tsuchie Hiroyuki Department of Orthopedic Surgery, Nakadoori General Hospital, Akita, Japan aut NATIONALLICENCE 700 1- Sasaki Hiroshi Department of Orthopedic Surgery, Akita-Rosai Hospital, Odate, Japan aut NATIONALLICENCE 700 1- Kasukawa Yuji Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan aut NATIONALLICENCE 700 1- Shimada Yoichi Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 553-559 0914-8779 33:5<553 2015 33 774