caa a22 4500 605463484 CHVBK 20210128100253.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00774-014-0569-7 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0569-7 Roles of leptin in bone metabolism and bone diseases [Elektronische Daten] [Xu Chen, Tianfu Yang] Adipose tissue has been more accepted as an active contributor to whole body homeostasis, rather than just a fat depot, since leptin, a 16kDa protein, was discovered as the product of the obese gene in 1994. With more and more studies conducted on this hormone, it has been shown that there is a close relationship between adipose tissue and bone, which have important effects on each other. Bone is the source of many hormones, such as osteocalcin, that can affect energy metabolism and then the anabolism or catabolism of fat tissue. In contrast, the adipose tissue synthesizes and releases a series of adipokines, which are involved in bone metabolism through direct or indirect effects on bone formation and resorption. Interestingly, leptin, one of the most important cytokines derived from fat tissue, seems to account for the largest part of effects on bone, through direct or indirect involvement in bone remodeling and by playing a significant role in many bone diseases, such as osteoporosis, osteoarthritis, rheumatic arthritis, bone tumors and even fractures. In this review, we will discuss the progress in leptin research, particularly focusing on the roles of leptin in bone diseases. The Japanese Society for Bone and Mineral Research and Springer Japan, 2015 Bone diseases nationallicence Bone metabolism nationallicence Leptin nationallicence Osteoarthritis nationallicence Osteoporosis nationallicence Chen Xu Department of Orthopedic Surgery, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 610041, Chengdu, Sichuan, People's Republic of China aut Yang Tianfu Department of Orthopedic Surgery, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 610041, Chengdu, Sichuan, People's Republic of China aut Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 474-485 0914-8779 33:5<474 2015 33 774 https://doi.org/10.1007/s00774-014-0569-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0569-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Xu Department of Orthopedic Surgery, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Yang Tianfu Department of Orthopedic Surgery, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 474-485 0914-8779 33:5<474 2015 33 774