caa a22 4500 605463506 CHVBK 20210128100253.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00774-014-0623-5 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0623-5 Clinical efficacy of oral risedronate therapy in Japanese patients with Paget's disease of bone [Elektronische Daten] [Masaya Ohara, Yasuo Imanishi, Yuki Nagata, Akira Ishii, Ikue Kobayashi, Katsuhito Mori, Manabu Ito, Takami Miki, Yoshiki Nishizawa, Masaaki Inaba] Paget's disease of bone (PDB) is a chronic disorder characterized by localized bone regions with excessive bone turnover. Although oral risedronate (17.5mg daily for 8weeks) was recently approved in Japan, its efficacy is not well understood. We retrospectively examined the efficacy of oral risedronate in PDB patients in a clinical setting. Eleven patients whose serum alkaline phosphatase (ALP) level exceeded the upper limit of the normal range were treated. Patients whose ALP levels normalized and remained so for 12months after therapy initiation were defined as responders. Treatment was repeated if bone pain recurred or if serum ALP levels increased at least 25% above the nadir. Six patients (55%) were responsive to the therapy. A higher prevalence of skull lesions, higher serum calcium levels at treatment initiation and antecedent treatments of bisphosphonates were predictors of resistance against the therapy. Fresh frozen serum samples obtained from some treatment sessions were evaluated for metabolic bone markers such as bone-specific ALP (BAP), type I procollagen N-terminal pro-peptide (PINP), N-treminal crosslinking telopeptide of type I collagen and C-treminal crosslinking telopeptide of type I collagen (CTX). A significant reduction of P1NP preceded that of serum ALP levels in the responders, which was followed by a similar occurrence for BAP and osteocalcin (BGP) levels. A temporary decrease in CTX levels was noted. No significant changes in markers (including ALP level) were observed in non-responder and repeat-treatment groups. P1NP levels may be more useful than ALP levels in assessing treatment efficacy. Repeat treatment effectiveness for the repeat-treatment group was limited. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Paget's disease of bone nationallicence Risedronate nationallicence Alkaline phosphatase (ALP) nationallicence Bone-specific ALP (BAP) nationallicence Type I procollagen N-terminal pro-peptide (PINP) nationallicence Ohara Masaya Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut Imanishi Yasuo Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut Nagata Yuki Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut Ishii Akira Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan aut Kobayashi Ikue Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut Mori Katsuhito Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut Ito Manabu Department of Orthopaedics, Hokkaido University School of Medicine, Sapporo, Japan aut Miki Takami Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan aut Nishizawa Yoshiki Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut Inaba Masaaki Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 584-590 0914-8779 33:5<584 2015 33 774 https://doi.org/10.1007/s00774-014-0623-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0623-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohara Masaya Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Imanishi Yasuo Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Nagata Yuki Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Ishii Akira Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Kobayashi Ikue Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Mori Katsuhito Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Ito Manabu Department of Orthopaedics, Hokkaido University School of Medicine, Sapporo, Japan aut NATIONALLICENCE 700 1- Miki Takami Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Nishizawa Yoshiki Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Inaba Masaaki Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-Ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/5(2015-09-01), 584-590 0914-8779 33:5<584 2015 33 774