What is the role of bosentan in healing of femur fractures in a rat model?
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0622-6 |2 doi |
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| 245 | 0 | 0 | |a What is the role of bosentan in healing of femur fractures in a rat model? |h [Elektronische Daten] |c [Ali Aydin, Zekai Halici, Erol Akpinar, A. Aksakal, Murat Saritemur, Muhammed Yayla, C. Kunak, Elif Cadirci, H. Atmaca, S. Karcioglu] |
| 520 | 3 | |a The purpose of this study was to examine the effects bosentan (which is a strong vasoconstrictor) on bone fracture pathophysiology, and investigate the roles of the nonselective endothelin1 receptor blocker bosentan on the bone fractures formed in rats through radiographic, histopathologic, and immunohistochemical methods. The rats were divided into three groups (six rats in each group): a femoral fracture control group, a femoral fractureplus bosentan at 50mg/kg group, and a femoral fracture plus bosentan at 100mg/kg group. The femoral fracture model was established by transversely cutting the femur at the midsection. After manual reduction, the fractured femur was fixed with intramedullary Kirschner wires. The radiographic healing scores of the bosentan 100 and 50mg/kg groups were significantly better that those of the fracture control group. The fracture callus percent of new bone in the bosentan 100mg/kg group was significantly greater than that in the control group. Also, semiquantitative analysis showed higher positive vascular endothelial growth factor and osteocalcin staining and lower positive endothelinreceptor typeA staining in the treatment groups than in the control group. Bosentan treatment also decreased tissue endothelin1 expression relative to that in the fracture control group. As a result of our study, the protective effect of bosentan was shown in experimental femoral fracture healing in rats by radiographic, histopathologic, and molecular analyses. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Bosentan |2 nationallicence | |
| 690 | 7 | |a Endothelin1 |2 nationallicence | |
| 690 | 7 | |a Bone fracture |2 nationallicence | |
| 690 | 7 | |a Rat |2 nationallicence | |
| 690 | 7 | |a Femur |2 nationallicence | |
| 700 | 1 | |a Aydin |D Ali |u Department of Orthopedics and Traumatology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | |
| 700 | 1 | |a Halici |D Zekai |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | |
| 700 | 1 | |a Akpinar |D Erol |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | |
| 700 | 1 | |a Aksakal |D A. |u Department of Orthopedics and Traumathology, Sevket Yilmaz Education and Research Hospital, 16230, Bursa, Turkey |4 aut | |
| 700 | 1 | |a Saritemur |D Murat |u Department of Emergency Medicine, Ataturk University Faculty of Pharmacy, 25240, Erzurum, Turkey |4 aut | |
| 700 | 1 | |a Yayla |D Muhammed |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | |
| 700 | 1 | |a Kunak |D C. |u Department of Pharmacology, Ordu University Faculty of Medicine, 52240, Ordu, Turkey |4 aut | |
| 700 | 1 | |a Cadirci |D Elif |u Department of Pharmacology, Ataturk University Faculty of Pharmacy, 25240, Erzurum, Turkey |4 aut | |
| 700 | 1 | |a Atmaca |D H. |u Department of Pathology, Kırıkkale University Faculty of Veterinary, 71240, Kırıkkale, Turkey |4 aut | |
| 700 | 1 | |a Karcioglu |D S. |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/5(2015-09-01), 496-506 |x 0914-8779 |q 33:5<496 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0622-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0622-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aydin |D Ali |u Department of Orthopedics and Traumatology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Halici |D Zekai |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Akpinar |D Erol |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aksakal |D A. |u Department of Orthopedics and Traumathology, Sevket Yilmaz Education and Research Hospital, 16230, Bursa, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Saritemur |D Murat |u Department of Emergency Medicine, Ataturk University Faculty of Pharmacy, 25240, Erzurum, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yayla |D Muhammed |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kunak |D C. |u Department of Pharmacology, Ordu University Faculty of Medicine, 52240, Ordu, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cadirci |D Elif |u Department of Pharmacology, Ataturk University Faculty of Pharmacy, 25240, Erzurum, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Atmaca |D H. |u Department of Pathology, Kırıkkale University Faculty of Veterinary, 71240, Kırıkkale, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Karcioglu |D S. |u Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/5(2015-09-01), 496-506 |x 0914-8779 |q 33:5<496 |1 2015 |2 33 |o 774 | ||