caa a22 4500 605463549 CHVBK 20210128100254.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00774-014-0573-y doi (NATIONALLICENCE)springer-10.1007/s00774-014-0573-y Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study [Elektronische Daten] [Noriko Yoshimura, Toru Akune, Saeko Fujiwara, Yoko Shimizu, Hideyo Yoshida, Yuji Nishiwaki, Akihiro Sudo, Go Omori, Munehito Yoshida, Hiroshi Shimokata, Takao Suzuki, Shigeyuki Muraki, Hiroyuki Oka, Kozo Nakamura] We investigated the incidence of disability and its risk factors in older Japanese adults to establish an evidence-based disability prevention strategy for this population. For this purpose, we used data from the Longitudinal Cohorts of Motor System Organ (LOCOMO) study, initiated in 2008 to integrate information from cohorts in nine communities across Japan: Tokyo (two regions), Wakayama (two regions), Hiroshima, Niigata, Mie, Akita, and Gunma prefectures. We examined the annual occurrence of disability from 8,454 individuals (2,705 men and 5,749 women) aged ≥65years. The estimated incidence of disability was 3.58/100 person-years (p-y) (men: 3.17/100 p-y; women: 3.78/100 p-y). To determine factors associated with disability, Cox's proportional hazard model was used, with the occurrence of disability as an objective variable and age (+1year), gender (vs. women), body build (0: normal/overweight range, BMI 18.5-27.5kg/m2; 1: emaciation, BMI <18.5kg/m2; 2: obesity, BMI >27.5kg/m2), and regional differences (0: rural areas including Wakayama, Niigata, Mie, Akita, and Gunma vs. 1: urban areas including Tokyo and Hiroshima) as explanatory variables. Age, body build, and regional difference significantly influenced the occurrence of disability (age, +1year: hazard ratio 1.13, 95% confidence interval 1.12-1.15, p<0.001; body build, vs. emaciation: 1.24, 1.01-1.53, p=0.041; body build, vs. obesity: 1.36, 1.08-1.71, p=0.009; residence, vs. living in rural areas: 1.59, 1.37-1.85, p<0.001). We concluded that higher age, both emaciation and obesity, and living in rural areas would be risk factors for the occurrence of disability. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Nation-wide population-based cohort study nationallicence Epidemiology nationallicence Incidence nationallicence Disability nationallicence Body build nationallicence Yoshimura Noriko Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Akune Toru Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut Fujiwara Saeko Hiroshima Atomic Bomb Causality Council, Hiroshima, Japan aut Shimizu Yoko Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Yoshida Hideyo Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Nishiwaki Yuji Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan aut Sudo Akihiro Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan aut Omori Go Center for Transdisciplinary Research, Institute for Research Promotion, Niigata University, Niigata, Japan aut Yoshida Munehito Department of Orthopedic Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan aut Shimokata Hiroshi Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Aichi, Japan aut Suzuki Takao National Center for Geriatrics and Gerontology, Aichi, Japan aut Muraki Shigeyuki Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut Oka Hiroyuki Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Nakamura Kozo National Rehabilitation Center for Persons with Disabilities, Saitama, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 186-191 0914-8779 33:2<186 2015 33 774 https://doi.org/10.1007/s00774-014-0573-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0573-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshimura Noriko Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Akune Toru Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujiwara Saeko Hiroshima Atomic Bomb Causality Council, Hiroshima, Japan aut NATIONALLICENCE 700 1- Shimizu Yoko Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Yoshida Hideyo Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Nishiwaki Yuji Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan aut NATIONALLICENCE 700 1- Sudo Akihiro Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan aut NATIONALLICENCE 700 1- Omori Go Center for Transdisciplinary Research, Institute for Research Promotion, Niigata University, Niigata, Japan aut NATIONALLICENCE 700 1- Yoshida Munehito Department of Orthopedic Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan aut NATIONALLICENCE 700 1- Shimokata Hiroshi Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Aichi, Japan aut NATIONALLICENCE 700 1- Suzuki Takao National Center for Geriatrics and Gerontology, Aichi, Japan aut NATIONALLICENCE 700 1- Muraki Shigeyuki Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Oka Hiroyuki Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Kozo National Rehabilitation Center for Persons with Disabilities, Saitama, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 186-191 0914-8779 33:2<186 2015 33 774