caa a22 4500 605463557 CHVBK 20210128100254.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00774-014-0583-9 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0583-9 Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study [Elektronische Daten] [Ryohei Kagotani, Munehito Yoshida, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Hashizume, Hiroshi Yamada, Yoshio Enyo, Keiji Nagata, Yuyu Ishimoto, Masatoshi Teraguchi, Sakae Tanaka, Kozo Nakamura, Hiroshi Kawaguchi, Toru Akune, Noriko Yoshimura] We aimed to assess the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) and its association with lumbar spondylosis (LS) and knee osteoarthritis (KOA) using a population-based cohort study entitled Research on Osteoarthritis/osteoporosis Against Disability (ROAD). In the baseline ROAD study, which was performed between 2005 and 2007, 1,690 participants in mountainous and coastal areas underwent anthropometric measurements and radiographic examinations of the whole spine (cervical, thoracic, and lumbar) and both knees. They also completed an interviewer-administered questionnaire. Presence of DISH was diagnosed according to Resnick criteria, and LS and KOA were defined as Kellgren-Lawrence (KL) grade ≥3. Among the 1,690 participants, whole-spine radiographs of 1,647 individuals (97.5%; 573 men, 1,074 women; mean age, 65.3years) were evaluated. Prevalence of DISH was 10.8% (men 22.0%, women 4.8%), and was significantly higher in older participants (presence of DISH 72.3years, absence of DISH 64.4years) and mainly distributed at the thoracic spine (88.7%). Logistic regression analysis revealed that presence of DISH was significantly associated with older age [+1year, odds ratio (OR): 1.06, 95% confidence interval (CI): 1.03-1.14], male sex (OR: 5.55, 95% CI: 3.57-8.63), higher body mass index (+1kg/m2, OR: 1.08, 95% CI: 1.02-1.14), presence of LS (KL2 vs KL0: 1, OR: 5.50, 95% CI: 2.81-10.8) (KL ≥3 vs KL0: 1, OR: 4.09, 95% CI: 2.08-8.03), and presence of KOA (KL ≥3 vs KL0: 1, OR: 1.89, 95% CI: 1.14-3.10) after adjusting for smoking, alcohol consumption, and residential area (mountainous vs coastal). This cross-sectional population-based study clarified the prevalence of DISH in general inhabitants and its significant association with LS and severe KOA. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Prevalence nationallicence Diffuse idiopathic skeletal hyperostosis nationallicence Knee osteoarthritis nationallicence Lumbar spondylosis nationallicence ROAD study nationallicence Kagotani Ryohei Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Yoshida Munehito Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Muraki Shigeyuki Department of Clinical Motor System Medicine, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Oka Hiroyuki Department of Joint Disease Research, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Hashizume Hiroshi Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Yamada Hiroshi Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Enyo Yoshio Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Nagata Keiji Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Ishimoto Yuyu Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Teraguchi Masatoshi Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut Tanaka Sakae Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Nakamura Kozo Rehabilitation Services Bureau, National Rehabilitation Centre for Persons with Disabilities, Tokorozawa, Japan aut Kawaguchi Hiroshi Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Akune Toru Department of Clinical Motor System Medicine, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Yoshimura Noriko Department of Joint Disease Research, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 221-229 0914-8779 33:2<221 2015 33 774 https://doi.org/10.1007/s00774-014-0583-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0583-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kagotani Ryohei Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Yoshida Munehito Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Muraki Shigeyuki Department of Clinical Motor System Medicine, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Oka Hiroyuki Department of Joint Disease Research, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Hashizume Hiroshi Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Yamada Hiroshi Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Enyo Yoshio Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Nagata Keiji Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Ishimoto Yuyu Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Teraguchi Masatoshi Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, 641-8509, Wakayama, Japan aut NATIONALLICENCE 700 1- Tanaka Sakae Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Kozo Rehabilitation Services Bureau, National Rehabilitation Centre for Persons with Disabilities, Tokorozawa, Japan aut NATIONALLICENCE 700 1- Kawaguchi Hiroshi Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Akune Toru Department of Clinical Motor System Medicine, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Yoshimura Noriko Department of Joint Disease Research, 22nd Century Medical and Research Centre, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 221-229 0914-8779 33:2<221 2015 33 774