caa a22 4500 605463573 CHVBK 20210128100254.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00774-014-0572-z doi (NATIONALLICENCE)springer-10.1007/s00774-014-0572-z Factors associated with low bone mineral density in patients with cystic fibrosis [Elektronische Daten] [Shahid Sheikh, Susan Gemma, Alpa Patel] Osteoporosis associated with cystic fibrosis is becoming more important as the life expectancy of patients continues to improve. This study was done to determine the prevalence of osteoporosis and osteopenia in CF patients and to identify risk factors. We reviewed the medical charts of 103 adults and adolescents with Cystic Fibrosis who had undergone a dual energy X-ray absorptiometry (DEXA) scan to measure the bone mineral content of the lumbar spine (L1-L4). Disease severity was assessed by lung function and body mass index (BMI) was calculated from weight and height at the time of the DEXA. None of the patients were being treated for low BMD. Random blood samples were analyzed for biochemical markers. The relationship between all these variables and BMD measurements was analyzed. Of 103 patients, ten (9.7%) patients (9 males, 1 female) were diagnosed with osteoporosis. An additional 36 (35%) patients (26 males, 10 females) were identified as having osteopenia. BMI, gender, weight, lung functions (FVC, FEV1, and FEF 25-75), and alkaline phosphatase, and 25-OH vitamin D levels were significantly correlated with Z-scores (p<0.05). Stepwise linear regression revealed that a low Z-score was best predicted with low FEV1, male gender, low weight, and low 25-OH vitamin D levels (p<0.05) for each variable. Osteopenia and osteoporosis are common in adults with CF, especially in male patients and in patients with low lung function, body weight, and 25-OH vitamin D levels. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Cystic fibrosis nationallicence FEV1 nationallicence 25-OH vitamin D nationallicence Osteoporosis nationallicence Osteopenia nationallicence BMI : Body mass index nationallicence CF : Cystic fibrosis nationallicence DEXA : Dual energy X-ray absorptiometry nationallicence FEV1 : Forced expiratory volume in one second nationallicence Sheikh Shahid Division of Pulmonary Medicine, Department of Pediatrics, Nationwide Children's Hospital, ED 444 700 Children's Drive, 43205, Columbus, OH, USA aut Gemma Susan Division of Pulmonary Medicine, Department of Pediatrics, Nationwide Children's Hospital, ED 444 700 Children's Drive, 43205, Columbus, OH, USA aut Patel Alpa Division of Pulmonary Medicine, Department of Pediatrics, Nationwide Children's Hospital, ED 444 700 Children's Drive, 43205, Columbus, OH, USA aut Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 180-185 0914-8779 33:2<180 2015 33 774 https://doi.org/10.1007/s00774-014-0572-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0572-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sheikh Shahid Division of Pulmonary Medicine, Department of Pediatrics, Nationwide Children's Hospital, ED 444 700 Children's Drive, 43205, Columbus, OH, USA aut NATIONALLICENCE 700 1- Gemma Susan Division of Pulmonary Medicine, Department of Pediatrics, Nationwide Children's Hospital, ED 444 700 Children's Drive, 43205, Columbus, OH, USA aut NATIONALLICENCE 700 1- Patel Alpa Division of Pulmonary Medicine, Department of Pediatrics, Nationwide Children's Hospital, ED 444 700 Children's Drive, 43205, Columbus, OH, USA aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 180-185 0914-8779 33:2<180 2015 33 774