Mycobacterium tuberculosis promotes arthritis development through toll-like receptor 2
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0575-9 |2 doi |
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| 245 | 0 | 0 | |a Mycobacterium tuberculosis promotes arthritis development through toll-like receptor 2 |h [Elektronische Daten] |c [Hiroya Kanagawa, Yasuo Niki, Tami Kobayashi, Yuiko Sato, Eri Katsuyama, Atsuhiro Fujie, Wu Hao, Kana Miyamoto, Toshimi Tando, Ryuichi Watanabe, Mayu Morita, Hideo Morioka, Morio Matsumoto, Yoshiaki Toyama, Takeshi Miyamoto] |
| 520 | 3 | |a Rheumatoid arthritis (RA) is a multifactorial disease caused by genetic and environmental factors: however, precise molecular mechanisms underlying its pathogenesis remain largely unknown. Treatment of RA patients with disease-modifying biological agents occasionally promotes Mycobacterium tuberculosis infection or recurrence of M. tuberculosis, although how infection promotes arthritis has not been characterized. Here, we found that arthritis phenotypes in a collagen-induced mouse model were evident only when killed M. tuberculosis was co-administered. Treatment of cultured macrophages with killed M. tuberculosis promoted production of IL-6, a major inflammatory cytokine in RA patients, while similar treatment of TLR2-deficient macrophages failed to induce IL-6 expression. Arthritis scores, joint destruction, and serum IL-6 levels were all significantly ameliorated in TLR2-deficient compared with wild-type mice, even in animals treated with killed M. tuberculosis. These results suggest that M. tuberculosis infection enhances arthritis development and that TLR2 could serve as a therapeutic target for some forms of the disease. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Mycobacterium tuberculosis |2 nationallicence | |
| 690 | 7 | |a Rheumatoid arthritis |2 nationallicence | |
| 690 | 7 | |a Toll-like receptor 2 |2 nationallicence | |
| 690 | 7 | |a IL-6 |2 nationallicence | |
| 690 | 7 | |a RA : Rheumatoid arthritis |2 nationallicence | |
| 690 | 7 | |a TLRs : Toll-like receptors |2 nationallicence | |
| 690 | 7 | |a CIA : Collagen-induced arthritis |2 nationallicence | |
| 700 | 1 | |a Kanagawa |D Hiroya |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Niki |D Yasuo |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Kobayashi |D Tami |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Sato |D Yuiko |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Katsuyama |D Eri |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Fujie |D Atsuhiro |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Hao |D Wu |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Miyamoto |D Kana |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Tando |D Toshimi |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Watanabe |D Ryuichi |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Morita |D Mayu |u Department of Dentistry and Oral Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Morioka |D Hideo |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Matsumoto |D Morio |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Toyama |D Yoshiaki |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Miyamoto |D Takeshi |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 135-141 |x 0914-8779 |q 33:2<135 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0575-9 |q text/html |z Onlinezugriff via DOI |
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| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0575-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kanagawa |D Hiroya |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Niki |D Yasuo |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kobayashi |D Tami |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sato |D Yuiko |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Katsuyama |D Eri |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fujie |D Atsuhiro |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hao |D Wu |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Miyamoto |D Kana |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tando |D Toshimi |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Watanabe |D Ryuichi |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morita |D Mayu |u Department of Dentistry and Oral Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morioka |D Hideo |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsumoto |D Morio |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Toyama |D Yoshiaki |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Miyamoto |D Takeshi |u Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 135-141 |x 0914-8779 |q 33:2<135 |1 2015 |2 33 |o 774 | ||