Effect of Urocortin on strength and microarchitecture of osteopenic rat femur
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0578-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0578-6 | ||
| 245 | 0 | 0 | |a Effect of Urocortin on strength and microarchitecture of osteopenic rat femur |h [Elektronische Daten] |c [Mohammad Tezval, Silja Hansen, Ulrich Schmelz, Marina Komrakova, Klaus Stuermer, Stephan Sehmisch] |
| 520 | 3 | |a As yet there is no evidence of the potential antiosteoporotic effect of Urocortin-1 (UCN), a corticotropin releasing factor related peptide, in vivo. In this study, and for the first time, we investigated the effect of UCN in a rat osteopenia model. Sixty female Sprague-Dawley rats were divided into 5groups: (1) sham-operated, (2) untreated ovariectomized (OVX) rats, (3) and (4) OVX animals treated for 5weeks with daily subcutaneous low-dose UCN (3μg/kg of BW) or high-dose UCN (30μg/kg of BW) 8weeks after ovariectomy, and (5) OVX rats treated with daily estrogen (0.2mg/kg of BW p.o) 8weeks after ovariectomy for 5weeks (E). After sacrifice, the femurs were reserved for biomechanical, histomorphometric and ash testing. In the biomechanical test, the high-dose UCN rats showed significantly improved mechanical stiffness (341.6N/mm) compared with the untreated OVX animals (275.9N/mm). In the histomorphometric evaluation, the high-dose UCN rats demonstrated an improved trabecular microarchitecture especially and significantly at the distal femur (distal femur Tb.Ar=41.4% and N.Nd/mm2=26.8, proximal femur Tb.Ar=71.8% and N.Nd/mm2=28.7) compared with untreated OVX rats (distal femur Tb.Ar=23.3% and N.Nd/mm2=11.7, proximal femur Tb.Ar=60.2% and N.Nd/mm2=25.2). Our results show that short-term treatment with UCN seems to have a positive effect on the metaphyseal bone structure and strength of the femur in ovariectomized rats. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Urocortin-1 |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Femur |2 nationallicence | |
| 690 | 7 | |a Ovariectomized rat |2 nationallicence | |
| 690 | 7 | |a Bone quality |2 nationallicence | |
| 700 | 1 | |a Tezval |D Mohammad |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | |
| 700 | 1 | |a Hansen |D Silja |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | |
| 700 | 1 | |a Schmelz |D Ulrich |u Medical Institute of General Hygiene and Environmental Health, University of Goettingen, Goettingen, Germany |4 aut | |
| 700 | 1 | |a Komrakova |D Marina |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | |
| 700 | 1 | |a Stuermer |D Klaus |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | |
| 700 | 1 | |a Sehmisch |D Stephan |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 154-160 |x 0914-8779 |q 33:2<154 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0578-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0578-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tezval |D Mohammad |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hansen |D Silja |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schmelz |D Ulrich |u Medical Institute of General Hygiene and Environmental Health, University of Goettingen, Goettingen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Komrakova |D Marina |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stuermer |D Klaus |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sehmisch |D Stephan |u Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 154-160 |x 0914-8779 |q 33:2<154 |1 2015 |2 33 |o 774 | ||