Efficacy and safety of eldecalcitol, a new active vitamin D3 analog, in the bone metabolism of postmenopausal women receiving maintenance hemodialysis
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605463611 | ||
| 003 | CHVBK | ||
| 005 | 20210128100254.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150301xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00774-014-0582-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0582-x | ||
| 245 | 0 | 0 | |a Efficacy and safety of eldecalcitol, a new active vitamin D3 analog, in the bone metabolism of postmenopausal women receiving maintenance hemodialysis |h [Elektronische Daten] |c [Naomi Sasaki, Masataka Tsunoda, Ryota Ikee, Nobuo Hashimoto] |
| 520 | 3 | |a Eldecalcitol (ELD), a new active vitamin D3 analog developed in Japan, has attracted attention as an effective osteoporotic therapeutic drug. However, because ELD leads to greater calcium absorption than does conventional active vitamin D3, it has yet to be used in patients with renal insufficiency. Therefore, we evaluated the efficacy and safety of ELD treatment in 27 postmenopausal women receiving maintenance dialysis in our institution and underwent ELD treatment (starting at 0.5μg/day) for 6months. The mean serum albumin-corrected calcium (Caalb) level was significantly increased following treatment (9.01±0.60 before versus 9.56±0.55 after treatment, mean±SD). Severe hypercalcemia was prevented through cessation or adjustment of the dosage of calcium-containing phosphate binders or existing active vitamin D. The mean serum phosphorus and intact parathyroid hormone levels were well-controlled throughout. The median levels of bone turnover markers, bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b were significantly decreased. The mean lumbar spine bone mineral density (BMD) was increased, a significant difference being observed in age-matched Z-scores (−0.60±1.6 versus −0.36±1.5, p=0.018). The average change in lumbar spine BMD after ELD treatment was 3.10%, and in patients with a T-score of <−4.0, it was 5.63%. There was no effect on forearm BMD. Although this study is based on short-term observation in a single institution, our results suggest that ELD could be used to increase bone density in dialysis patients. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Eldecalcitol |2 nationallicence | |
| 690 | 7 | |a Bone metabolism |2 nationallicence | |
| 690 | 7 | |a Postmenopausal |2 nationallicence | |
| 690 | 7 | |a Dialysis |2 nationallicence | |
| 700 | 1 | |a Sasaki |D Naomi |u Department of Nephrology and Dialysis, H.N.MEDIC, 6-1-5, Atsubetsuchuo-5, Atsubetsu-ku, 004-0055, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Tsunoda |D Masataka |u Department of Nephrology and Dialysis, H.N.MEDIC Sapporohigashi, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Ikee |D Ryota |u Department of Nephrology and Dialysis, H.N.MEDIC Kitahiroshima, Kitahiroshima, Japan |4 aut | |
| 700 | 1 | |a Hashimoto |D Nobuo |u Department of Nephrology and Dialysis, H.N.MEDIC, 6-1-5, Atsubetsuchuo-5, Atsubetsu-ku, 004-0055, Sapporo, Japan |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 213-220 |x 0914-8779 |q 33:2<213 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0582-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0582-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sasaki |D Naomi |u Department of Nephrology and Dialysis, H.N.MEDIC, 6-1-5, Atsubetsuchuo-5, Atsubetsu-ku, 004-0055, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsunoda |D Masataka |u Department of Nephrology and Dialysis, H.N.MEDIC Sapporohigashi, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ikee |D Ryota |u Department of Nephrology and Dialysis, H.N.MEDIC Kitahiroshima, Kitahiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hashimoto |D Nobuo |u Department of Nephrology and Dialysis, H.N.MEDIC, 6-1-5, Atsubetsuchuo-5, Atsubetsu-ku, 004-0055, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 213-220 |x 0914-8779 |q 33:2<213 |1 2015 |2 33 |o 774 | ||