Inhibitory effect of bisphosphonate on osteoclast function contributes to improved skeletal pain in ovariectomized mice
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0574-x |2 doi |
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| 245 | 0 | 0 | |a Inhibitory effect of bisphosphonate on osteoclast function contributes to improved skeletal pain in ovariectomized mice |h [Elektronische Daten] |c [Yasuhisa Abe, Kousuke Iba, Koichi Sasaki, Hironori Chiba, Kumiko Kanaya, Tomoyuki Kawamata, Kimimitsu Oda, Norio Amizuka, Muneteru Sasaki, Toshihiko Yamashita] |
| 520 | 3 | |a The aim of this study was to evaluate skeletal pain associated with osteoporosis and to examine the inhibitory effect of bisphosphonate (BP) on pain in an ovariectomized (OVX) mouse model. We evaluated skeletal pain in OVX mice through an examination of pain-like behavior as well as immunohistochemical findings. In addition, we assessed the effects of alendronate (ALN), a potent osteoclast inhibitor, on those parameters. The OVX mice showed a decrease in the pain threshold value, and an increase in the number of c-Fos immunoreactive neurons in laminae I-II of the dorsal horn of the spinal cord. Alendronate caused an increase in the pain threshold value and inhibited c-Fos expression. The serum level of tartrate-resistant acid phosphatase 5b, a marker of osteoclast activity, was significantly negatively correlated with the pain threshold value. Furthermore, we found that an antagonist of the transient receptor potential channel vanilloid subfamily member 1, which is an acid-sensing nociceptor, improved pain-like behavior in OVX mice. These results indicated that the inhibitory effect of BP on osteoclast function might contribute to an improvement in skeletal pain in osteoporosis patients. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Pain |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Osteoclast |2 nationallicence | |
| 690 | 7 | |a Bisphosphonate |2 nationallicence | |
| 690 | 7 | |a Transient receptor potential channel vanilloid subfamily member 1 (TRPV1) |2 nationallicence | |
| 700 | 1 | |a Abe |D Yasuhisa |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Iba |D Kousuke |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Sasaki |D Koichi |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Chiba |D Hironori |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kanaya |D Kumiko |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kawamata |D Tomoyuki |u Department of Anesthesiology and Resuscitology, Shinsyu University School of Medicine, Matsumoto, Japan |4 aut | |
| 700 | 1 | |a Oda |D Kimimitsu |u Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan |4 aut | |
| 700 | 1 | |a Amizuka |D Norio |u Department of Developmental Biology of Hard Tissue, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Sasaki |D Muneteru |u Department of Developmental Biology of Hard Tissue, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Yamashita |D Toshihiko |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 125-134 |x 0914-8779 |q 33:2<125 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0574-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0574-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Abe |D Yasuhisa |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Iba |D Kousuke |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sasaki |D Koichi |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chiba |D Hironori |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kanaya |D Kumiko |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kawamata |D Tomoyuki |u Department of Anesthesiology and Resuscitology, Shinsyu University School of Medicine, Matsumoto, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oda |D Kimimitsu |u Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Amizuka |D Norio |u Department of Developmental Biology of Hard Tissue, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sasaki |D Muneteru |u Department of Developmental Biology of Hard Tissue, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamashita |D Toshihiko |u Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 125-134 |x 0914-8779 |q 33:2<125 |1 2015 |2 33 |o 774 | ||