Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0579-5 |2 doi |
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| 245 | 0 | 0 | |a Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study |h [Elektronische Daten] |c [Grazia Morandi, E. Maines, C. Piona, E. Monti, M. Sandri, R. Gaudino, A. Boner, F. Antoniazzi] |
| 520 | 3 | |a The aim of our study was to analyze the possible relationship between growing pains, vitamin D levels, and bone mineral status. We enrolled 33 children affected by growing pains. Their pain intensity was evaluated through a questionnaire using the Wong-Baker Faces Pain Rating Scale for pain assessment. Serum 25-hydroxyvitamin D (25-OH-D), parathyroid hormone (PTH), and alkaline phosphatase levels were measured as well. A quantitative ultrasound assessment (QUS) was also done, measuring both the amplitude-dependent speed of sound (AD-SOS) and the bone transmission time (BTT), correlating, respectively, with bone density and with cortical thickness. After 3 and 24months of vitamin D supplementation, we re-evaluated pain intensity and laboratory results. After 24months we re-assessed QUS parameters. At the beginning of the study the children reported a mean growing pain intensity of 7.5±1.6 SD. The mean values of 25-OH-D and PTH levels were 15.7±6.9ng/ml and 57.3±27.3pg/ml, respectively. The AD-SOS Z score was −0.53±1.19 SD, and the mean value of the BTT Z score was −0.72±0.96 SD. After the first 3months of vitamin D supplementation we observed an increase in 25-OH-D levels (34.1±17.8, p<0.001) and a reduction in both PTH levels (47.3±30.6, p=0.135) and pain intensity (2.7±2.2, p<0.001). After 24months we observed a further significant reduction in the pain intensity (3.9±3.4, p<0.001) and in PTH levels (43.7±28.5, p=0.004) and an improvement in the QUS parameters, in particular in BTT Z scores (p=0.014). Our study suggests an interesting relationship between growing pains, vitamin D levels and bone mineral status. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Growing pains |2 nationallicence | |
| 690 | 7 | |a Vitamin D |2 nationallicence | |
| 690 | 7 | |a Parathyroid hormone |2 nationallicence | |
| 690 | 7 | |a Bone mineral status |2 nationallicence | |
| 690 | 7 | |a Quantitative ultrasound assessment |2 nationallicence | |
| 700 | 1 | |a Morandi |D Grazia |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | |
| 700 | 1 | |a Maines |D E. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | |
| 700 | 1 | |a Piona |D C. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | |
| 700 | 1 | |a Monti |D E. |u Complex Operative Unit of Pediatrics, Azienda Unita Locale Socio Sanitaria N. 21-Via Carlo Gianella, 37045, Legnago, Verona, Italy |4 aut | |
| 700 | 1 | |a Sandri |D M. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | |
| 700 | 1 | |a Gaudino |D R. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | |
| 700 | 1 | |a Boner |D A. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | |
| 700 | 1 | |a Antoniazzi |D F. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 201-206 |x 0914-8779 |q 33:2<201 |1 2015 |2 33 |o 774 | |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0579-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morandi |D Grazia |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maines |D E. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Piona |D C. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Monti |D E. |u Complex Operative Unit of Pediatrics, Azienda Unita Locale Socio Sanitaria N. 21-Via Carlo Gianella, 37045, Legnago, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sandri |D M. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gaudino |D R. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Boner |D A. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Antoniazzi |D F. |u Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 201-206 |x 0914-8779 |q 33:2<201 |1 2015 |2 33 |o 774 | ||