caa a22 4500 605463662 CHVBK 20210128100254.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00774-014-0579-5 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0579-5 Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study [Elektronische Daten] [Grazia Morandi, E. Maines, C. Piona, E. Monti, M. Sandri, R. Gaudino, A. Boner, F. Antoniazzi] The aim of our study was to analyze the possible relationship between growing pains, vitamin D levels, and bone mineral status. We enrolled 33 children affected by growing pains. Their pain intensity was evaluated through a questionnaire using the Wong-Baker Faces Pain Rating Scale for pain assessment. Serum 25-hydroxyvitamin D (25-OH-D), parathyroid hormone (PTH), and alkaline phosphatase levels were measured as well. A quantitative ultrasound assessment (QUS) was also done, measuring both the amplitude-dependent speed of sound (AD-SOS) and the bone transmission time (BTT), correlating, respectively, with bone density and with cortical thickness. After 3 and 24months of vitamin D supplementation, we re-evaluated pain intensity and laboratory results. After 24months we re-assessed QUS parameters. At the beginning of the study the children reported a mean growing pain intensity of 7.5±1.6 SD. The mean values of 25-OH-D and PTH levels were 15.7±6.9ng/ml and 57.3±27.3pg/ml, respectively. The AD-SOS Z score was −0.53±1.19 SD, and the mean value of the BTT Z score was −0.72±0.96 SD. After the first 3months of vitamin D supplementation we observed an increase in 25-OH-D levels (34.1±17.8, p<0.001) and a reduction in both PTH levels (47.3±30.6, p=0.135) and pain intensity (2.7±2.2, p<0.001). After 24months we observed a further significant reduction in the pain intensity (3.9±3.4, p<0.001) and in PTH levels (43.7±28.5, p=0.004) and an improvement in the QUS parameters, in particular in BTT Z scores (p=0.014). Our study suggests an interesting relationship between growing pains, vitamin D levels and bone mineral status. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Growing pains nationallicence Vitamin D nationallicence Parathyroid hormone nationallicence Bone mineral status nationallicence Quantitative ultrasound assessment nationallicence Morandi Grazia Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut Maines E. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut Piona C. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut Monti E. Complex Operative Unit of Pediatrics, Azienda Unita Locale Socio Sanitaria N. 21-Via Carlo Gianella, 37045, Legnago, Verona, Italy aut Sandri M. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut Gaudino R. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut Boner A. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut Antoniazzi F. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 201-206 0914-8779 33:2<201 2015 33 774 https://doi.org/10.1007/s00774-014-0579-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0579-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morandi Grazia Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Maines E. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Piona C. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Monti E. Complex Operative Unit of Pediatrics, Azienda Unita Locale Socio Sanitaria N. 21-Via Carlo Gianella, 37045, Legnago, Verona, Italy aut NATIONALLICENCE 700 1- Sandri M. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Gaudino R. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Boner A. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Antoniazzi F. Department of Life and Reproduction Sciences, Pediatric Clinic, Giambattista Rossi Hospital, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 201-206 0914-8779 33:2<201 2015 33 774