caa a22 4500 605463689 CHVBK 20210128100254.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00774-014-0570-1 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0570-1 The association between genetic variants of RUNX2 , ADIPOQ and vertebral fracture in Korean postmenopausal women [Elektronische Daten] [Kyong-Chol Kim, Hyejin Chun, ChaoQiang Lai, Laurence Parnell, Yangsoo Jang, Jongho Lee, Jose. Ordovas] Contrary to the traditional belief that obesity acts as a protective factor for bone, recent epidemiologic studies have shown that body fat might be a risk factor for osteoporosis and bone fracture. Accordingly, we evaluated the association between the phenotypes of osteoporosis or vertebral fracture and variants of obesity-related genes, peroxisome proliferator-activated receptor-gamma (PPARG), runt-related transcription factor 2 (RUNX2), leptin receptor (LEPR), and adiponectin (ADIPOQ). In total, 907 postmenopausal healthy women, aged 60-79years, were included in this study. BMD and biomarkers of bone health and adiposity were measured. We genotyped for four single nucleotide polymorphisms (SNPs) from four genes (PPARG, RUNX2, LEPR, ADIPOQ). A general linear model for continuous dependent variables and a logistic regression model for categorical dependent variables were used to analyze the statistical differences among genotype groups. Compared with the TT subjects at rs7771980 in RUNX2, C-carrier (TC+CC) subjects had a lower vertebral fracture risk after adjusting for age, smoking, alcohol, total calorie intake, total energy expenditure, total calcium intake, total fat intake, weight, body fat. Odds ratio (OR) and 95% interval (CI) for the vertebral fracture risk was 0.55 (95% CI 0.32-0.94). After adjusting for multiple variables, the prevalence of vertebral fracture was highest in GG subjects at rs1501299 in ADIPOQ (p=0.0473). A high calcium intake (>1000mg/day) contributed to a high bone mineral density (BMD) in GT+TT subjects at rs1501299 in ADIPOQ (p for interaction=0.0295). Even if the mechanisms between obesity-related genes and bone health are not fully established, the results of our study revealed the association of certain SNPs from obesity-related genes with BMD or vertebral fracture risk in postmenopausal Korean women. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Polymorphisms nationallicence Runt-related transcription factor 2 ( RUNX2 ) nationallicence Adiponectin ( ADIPOQ) nationallicence Osteoporosis nationallicence Vertebral fracture nationallicence Kim Kyong-Chol Department of Family Medicine, Chaum Hospital, Cha University, Seoul, Korea aut Chun Hyejin Health Promotion Center, Ewha Woman's University Mokdong Hospital Ewha Woman's University School of Medicine, Seoul, Korea aut Lai ChaoQiang Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut Parnell Laurence Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut Jang Yangsoo Graduate Program in Science for Aging, Yonsei University, Seoul, Korea aut Lee Jongho Graduate Program in Science for Aging, Yonsei University, Seoul, Korea aut Ordovas Jose Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 173-179 0914-8779 33:2<173 2015 33 774 https://doi.org/10.1007/s00774-014-0570-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0570-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Kyong-Chol Department of Family Medicine, Chaum Hospital, Cha University, Seoul, Korea aut NATIONALLICENCE 700 1- Chun Hyejin Health Promotion Center, Ewha Woman's University Mokdong Hospital Ewha Woman's University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lai ChaoQiang Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut NATIONALLICENCE 700 1- Parnell Laurence Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut NATIONALLICENCE 700 1- Jang Yangsoo Graduate Program in Science for Aging, Yonsei University, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jongho Graduate Program in Science for Aging, Yonsei University, Seoul, Korea aut NATIONALLICENCE 700 1- Ordovas Jose Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/2(2015-03-01), 173-179 0914-8779 33:2<173 2015 33 774