Hepatoprotective and antioxidant effects of phyllanthin against carbon tetrachloride-induced liver injury in Cyprinus carpio
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| 024 | 7 | 0 | |a 10.1007/s10499-014-9847-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10499-014-9847-6 | ||
| 245 | 0 | 0 | |a Hepatoprotective and antioxidant effects of phyllanthin against carbon tetrachloride-induced liver injury in Cyprinus carpio |h [Elektronische Daten] |c [Rui Jia, Jin-Liang Du, Li-Ping Cao, Ying-Juan Liu, Pao Xu, Guo-Jun Yin] |
| 520 | 3 | |a The aim of the present study was to investigate the protective effects and possible mechanism of phyllanthin against carbon tetrachloride (CCl4)-induced hepatic damage in common carp. Fish were fed diet containing four doses of phyllanthin (0, 100, 300, and 600mg/kg diet) for 60days, and then given an intraperitoneal injection of CCl4 (30% in arachis oil) at a dose of 0.5ml/kg body weight. At 72h after CCl4 injection, blood and liver samples were collected for the analyses of serum biochemical parameters, peroxidation product, glutathione, and antioxidant enzyme activities. The results showed that administration of phyllanthin at the doses of 300 and 600mg/kg in the diet prior to CCl4 intoxication considerably inhibited the adverse alterations caused by CCl4 in serum and liver tissue, including glutamate pyruvate transaminase, glutamate oxalate transaminase, lactate dehydrogenase, total protein, albumin, superoxide dismutase, glutathione peroxidase, catalase, glutathione, total antioxidant capacity and malondialdehyde. Furthermore, the positive effects of phyllanthin were confirmed in histopathologic examination. Overall results proved the hepatoprotection of phyllanthin, and it is suggested that phyllanthin may be used as a hepatoprotective agent to prevent liver diseases in fish. | |
| 540 | |a Springer International Publishing Switzerland, 2014 | ||
| 690 | 7 | |a Phyllanthin |2 nationallicence | |
| 690 | 7 | |a Carbon tetrachloride |2 nationallicence | |
| 690 | 7 | |a Hepatoprotective effect |2 nationallicence | |
| 690 | 7 | |a Cyprinus carpio |2 nationallicence | |
| 700 | 1 | |a Jia |D Rui |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | |
| 700 | 1 | |a Du |D Jin-Liang |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | |
| 700 | 1 | |a Cao |D Li-Ping |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | |
| 700 | 1 | |a Liu |D Ying-Juan |u Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, 214081, Wuxi, China |4 aut | |
| 700 | 1 | |a Xu |D Pao |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | |
| 700 | 1 | |a Yin |D Guo-Jun |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | |
| 773 | 0 | |t Aquaculture International |d Springer International Publishing |g 23/4(2015-08-01), 883-893 |x 0967-6120 |q 23:4<883 |1 2015 |2 23 |o 10499 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10499-014-9847-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10499-014-9847-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jia |D Rui |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Du |D Jin-Liang |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cao |D Li-Ping |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Ying-Juan |u Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, 214081, Wuxi, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Pao |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yin |D Guo-Jun |u Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, Jiangsu, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Aquaculture International |d Springer International Publishing |g 23/4(2015-08-01), 883-893 |x 0967-6120 |q 23:4<883 |1 2015 |2 23 |o 10499 | ||