Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat

Verfasser / Beitragende:
[Ringo Grombe, Günter Allmaier, Jean Charoud-Got, Agnieszka Dudkiewicz, Håkan Emteborg, Thilo Hofmann, Erik Larsen, Angela Lehner, Meritxell Llinàs, Katrin Loeschner, Kristian Mølhave, Ruud Peters, John Seghers, Conxita Solans, Frank von der Kammer, Stephan Wagner, Stefan Weigel, Thomas Linsinger]
Ort, Verlag, Jahr:
2015
Enthalten in:
Accreditation and Quality Assurance, 20/1(2015-02-01), 3-16
Format:
Artikel (online)
ID: 605465541
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024 7 0 |a 10.1007/s00769-014-1100-5  |2 doi 
035 |a (NATIONALLICENCE)springer-10.1007/s00769-014-1100-5 
245 0 0 |a Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat  |h [Elektronische Daten]  |c [Ringo Grombe, Günter Allmaier, Jean Charoud-Got, Agnieszka Dudkiewicz, Håkan Emteborg, Thilo Hofmann, Erik Larsen, Angela Lehner, Meritxell Llinàs, Katrin Loeschner, Kristian Mølhave, Ruud Peters, John Seghers, Conxita Solans, Frank von der Kammer, Stephan Wagner, Stefan Weigel, Thomas Linsinger] 
520 3 |a The feasibility of producing colloidal silver nanoparticle reference materials and silver nanoparticle spiked reference matrix materials was investigated. Two concentrations of PVP-coated silver nanoparticle dispersions were evaluated and used to spike chicken meat, with the aim of producing a set of reference materials to support the development of analytical methods for the detection and quantification of nanoparticles in food. Aqueous silver nanoparticle (AgNP) dispersions were evaluated for their homogeneity of mass fraction and particle size and found sufficiently homogeneous to be used as reference materials. Stability studies at 4°C, 18°C and 60°C demonstrated sufficient short- and long-term stability, although particle size decreases in a linear fashion at 60°C. The AgNP dispersions were characterized for total Ag mass fraction by ICP-OES, dissolved Ag content by ultrafiltration-ICP-MS, as well as AgNP particle size by dynamic light scattering, transmission electron microscopy (TEM) and gas-phase electrophoretic molecular mobility analysis. Chicken breasts were homogenized by cryo-milling and spiked with aqueous AgNP dispersions. Rapid freezing over liquid nitrogen resulted in homogeneous and stable materials. The spiked chicken materials were characterized for their total Ag mass fraction by neutron activation analysis and for the AgNP particle size by TEM and single-particle inductively coupled plasma mass spectrometry. The observed differences in particle sizes between the spiked chicken samples and the original silver dispersions indicate relevant matrix effects. The materials demonstrate that production and characterization of reference materials for the detection and quantification of silver nanoparticles in meat are feasible, but challenges especially in assessing stability and having sufficiently precise methods for assessment of homogeneity and stability remain. 
540 |a European Union, 2015 
690 7 |a Engineered nanoparticles  |2 nationallicence 
690 7 |a Food  |2 nationallicence 
690 7 |a Reference material  |2 nationallicence 
690 7 |a Matrix reference materials  |2 nationallicence 
690 7 |a Silver nanoparticles  |2 nationallicence 
700 1 |a Grombe  |D Ringo  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
700 1 |a Allmaier  |D Günter  |u Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria  |4 aut 
700 1 |a Charoud-Got  |D Jean  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
700 1 |a Dudkiewicz  |D Agnieszka  |u The Food and Environment Research Agency, YO41 1LZ, Sand Hutton York, UK  |4 aut 
700 1 |a Emteborg  |D Håkan  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
700 1 |a Hofmann  |D Thilo  |u Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria  |4 aut 
700 1 |a Larsen  |D Erik  |u National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark  |4 aut 
700 1 |a Lehner  |D Angela  |u Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria  |4 aut 
700 1 |a Llinàs  |D Meritxell  |u Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain  |4 aut 
700 1 |a Loeschner  |D Katrin  |u National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark  |4 aut 
700 1 |a Mølhave  |D Kristian  |u DTU Nanotech, Technical University of Denmark, DTU Bldg 345b, 2800, Lyngby, Denmark  |4 aut 
700 1 |a Peters  |D Ruud  |u RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland  |4 aut 
700 1 |a Seghers  |D John  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
700 1 |a Solans  |D Conxita  |u Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain  |4 aut 
700 1 |a von der Kammer  |D Frank  |u Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria  |4 aut 
700 1 |a Wagner  |D Stephan  |u Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria  |4 aut 
700 1 |a Weigel  |D Stefan  |u RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland  |4 aut 
700 1 |a Linsinger  |D Thomas  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
773 0 |t Accreditation and Quality Assurance  |d Springer Berlin Heidelberg  |g 20/1(2015-02-01), 3-16  |x 0949-1775  |q 20:1<3  |1 2015  |2 20  |o 769 
856 4 0 |u https://doi.org/10.1007/s00769-014-1100-5  |q text/html  |z Onlinezugriff via DOI 
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900 7 |a Metadata rights reserved  |b Springer special CC-BY-NC licence  |2 nationallicence 
908 |D 1  |a research-article  |2 jats 
949 |B NATIONALLICENCE  |F NATIONALLICENCE  |b NL-springer 
950 |B NATIONALLICENCE  |P 856  |E 40  |u https://doi.org/10.1007/s00769-014-1100-5  |q text/html  |z Onlinezugriff via DOI 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Grombe  |D Ringo  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Allmaier  |D Günter  |u Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Charoud-Got  |D Jean  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Dudkiewicz  |D Agnieszka  |u The Food and Environment Research Agency, YO41 1LZ, Sand Hutton York, UK  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Emteborg  |D Håkan  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Hofmann  |D Thilo  |u Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Larsen  |D Erik  |u National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Lehner  |D Angela  |u Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Llinàs  |D Meritxell  |u Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Loeschner  |D Katrin  |u National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Mølhave  |D Kristian  |u DTU Nanotech, Technical University of Denmark, DTU Bldg 345b, 2800, Lyngby, Denmark  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Peters  |D Ruud  |u RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Seghers  |D John  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Solans  |D Conxita  |u Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a von der Kammer  |D Frank  |u Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Wagner  |D Stephan  |u Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Weigel  |D Stefan  |u RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Linsinger  |D Thomas  |u European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Accreditation and Quality Assurance  |d Springer Berlin Heidelberg  |g 20/1(2015-02-01), 3-16  |x 0949-1775  |q 20:1<3  |1 2015  |2 20  |o 769