caa a22 4500 605465541 CHVBK 20210128100303.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00769-014-1100-5 doi (NATIONALLICENCE)springer-10.1007/s00769-014-1100-5 Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat [Elektronische Daten] [Ringo Grombe, Günter Allmaier, Jean Charoud-Got, Agnieszka Dudkiewicz, Håkan Emteborg, Thilo Hofmann, Erik Larsen, Angela Lehner, Meritxell Llinàs, Katrin Loeschner, Kristian Mølhave, Ruud Peters, John Seghers, Conxita Solans, Frank von der Kammer, Stephan Wagner, Stefan Weigel, Thomas Linsinger] The feasibility of producing colloidal silver nanoparticle reference materials and silver nanoparticle spiked reference matrix materials was investigated. Two concentrations of PVP-coated silver nanoparticle dispersions were evaluated and used to spike chicken meat, with the aim of producing a set of reference materials to support the development of analytical methods for the detection and quantification of nanoparticles in food. Aqueous silver nanoparticle (AgNP) dispersions were evaluated for their homogeneity of mass fraction and particle size and found sufficiently homogeneous to be used as reference materials. Stability studies at 4°C, 18°C and 60°C demonstrated sufficient short- and long-term stability, although particle size decreases in a linear fashion at 60°C. The AgNP dispersions were characterized for total Ag mass fraction by ICP-OES, dissolved Ag content by ultrafiltration-ICP-MS, as well as AgNP particle size by dynamic light scattering, transmission electron microscopy (TEM) and gas-phase electrophoretic molecular mobility analysis. Chicken breasts were homogenized by cryo-milling and spiked with aqueous AgNP dispersions. Rapid freezing over liquid nitrogen resulted in homogeneous and stable materials. The spiked chicken materials were characterized for their total Ag mass fraction by neutron activation analysis and for the AgNP particle size by TEM and single-particle inductively coupled plasma mass spectrometry. The observed differences in particle sizes between the spiked chicken samples and the original silver dispersions indicate relevant matrix effects. The materials demonstrate that production and characterization of reference materials for the detection and quantification of silver nanoparticles in meat are feasible, but challenges especially in assessing stability and having sufficiently precise methods for assessment of homogeneity and stability remain. European Union, 2015 Engineered nanoparticles nationallicence Food nationallicence Reference material nationallicence Matrix reference materials nationallicence Silver nanoparticles nationallicence Grombe Ringo European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut Allmaier Günter Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria aut Charoud-Got Jean European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut Dudkiewicz Agnieszka The Food and Environment Research Agency, YO41 1LZ, Sand Hutton York, UK aut Emteborg Håkan European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut Hofmann Thilo Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria aut Larsen Erik National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark aut Lehner Angela Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria aut Llinàs Meritxell Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain aut Loeschner Katrin National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark aut Mølhave Kristian DTU Nanotech, Technical University of Denmark, DTU Bldg 345b, 2800, Lyngby, Denmark aut Peters Ruud RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland aut Seghers John European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut Solans Conxita Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain aut von der Kammer Frank Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria aut Wagner Stephan Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria aut Weigel Stefan RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland aut Linsinger Thomas European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut Accreditation and Quality Assurance Springer Berlin Heidelberg 20/1(2015-02-01), 3-16 0949-1775 20:1<3 2015 20 769 https://doi.org/10.1007/s00769-014-1100-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00769-014-1100-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grombe Ringo European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut NATIONALLICENCE 700 1- Allmaier Günter Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Charoud-Got Jean European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut NATIONALLICENCE 700 1- Dudkiewicz Agnieszka The Food and Environment Research Agency, YO41 1LZ, Sand Hutton York, UK aut NATIONALLICENCE 700 1- Emteborg Håkan European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut NATIONALLICENCE 700 1- Hofmann Thilo Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Larsen Erik National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark aut NATIONALLICENCE 700 1- Lehner Angela Institute of Chemical Technologies and Analytics, Research Group Bio- and Polymer Analysis, Vienna University of Technology, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Llinàs Meritxell Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain aut NATIONALLICENCE 700 1- Loeschner Katrin National Food Institute, Technical University of Denmark, 19, Mørkhøj Bygade, 2860, Søborg, Denmark aut NATIONALLICENCE 700 1- Mølhave Kristian DTU Nanotech, Technical University of Denmark, DTU Bldg 345b, 2800, Lyngby, Denmark aut NATIONALLICENCE 700 1- Peters Ruud RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland aut NATIONALLICENCE 700 1- Seghers John European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut NATIONALLICENCE 700 1- Solans Conxita Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Institute of Advanced Chemistry and Centro de Investigaciones Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain aut NATIONALLICENCE 700 1- von der Kammer Frank Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Wagner Stephan Department of Environmental Geosciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Weigel Stefan RIKILT - Institute of Food Safety, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherland aut NATIONALLICENCE 700 1- Linsinger Thomas European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, 2440, Geel, Belgium aut NATIONALLICENCE 773 0- Accreditation and Quality Assurance Springer Berlin Heidelberg 20/1(2015-02-01), 3-16 0949-1775 20:1<3 2015 20 769