Homogeneity studies and ISO Guide 35:2006
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| 024 | 7 | 0 | |a 10.1007/s00769-015-1162-z |2 doi |
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| 100 | 1 | |a Ellison |D Stephen |u LGC Limited, Teddington, Middlesex, UK |4 aut | |
| 245 | 1 | 0 | |a Homogeneity studies and ISO Guide 35:2006 |h [Elektronische Daten] |c [Stephen Ellison] |
| 520 | 3 | |a Homogeneity assessment of reference materials is discussed with particular reference to the recommendations given in ISO Guide 35. It is suggested that Guide 35 could be improved by the addition of a wider range of experimental designs, and by using statistical power calculations to improve the recommendations for design of experiments for homogeneity assessment. It is further shown that the present recommended allowance for possible inhomogeneity uncertainty in the absence of a significant between-bottle effect does not have a sound statistical basis and is considerably smaller than an accurate upper 95% confidence limit for the between-unit term. Alternatives are considered, including the use of a more accurate (and usually much larger) calculation of possible between-unit variance, post hoc power calculation, and the simple use of the calculated between-unit variance coupled with increased emphasis on effective experimentation to limit the risk of underestimation. Recommendations for improved guidance are made. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Reference material certification |2 nationallicence | |
| 690 | 7 | |a Homogeneity studies |2 nationallicence | |
| 690 | 7 | |a ISO Guide 35 |2 nationallicence | |
| 773 | 0 | |t Accreditation and Quality Assurance |d Springer Berlin Heidelberg |g 20/6(2015-12-01), 519-528 |x 0949-1775 |q 20:6<519 |1 2015 |2 20 |o 769 | |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00769-015-1162-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 100 |E 1- |a Ellison |D Stephen |u LGC Limited, Teddington, Middlesex, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Accreditation and Quality Assurance |d Springer Berlin Heidelberg |g 20/6(2015-12-01), 519-528 |x 0949-1775 |q 20:6<519 |1 2015 |2 20 |o 769 | ||