caa a22 4500 60546653X CHVBK 20210128100307.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00397-014-0830-y doi (NATIONALLICENCE)springer-10.1007/s00397-014-0830-y A computational extensional rheology study of two biofluid systems [Elektronische Daten] [Jose López-Aguilar, Michael Webster, Alaa Al-Muslimawi, Hamid Tamaddon-Jahromi, Rhodri Williams, Karl Hawkins, Colin Askill, Chin Ch'ng, Gwyneth Davies, Phillip Ebden, Keir Lewis] The main focus of the present computational modelling work is to determine the extensional rheological response of some model biofluids, with a view to ultimately aiding experimentally based analyses and clinical practice. This is accomplished in the present study through model extensional flows and rheological investigation, addressing filament stretching and contraction flows, and upon which significant advances are presented. As such, two biofluid flow systems within the human body are of current interest: (i) respiratory disorders and sputum in the lung airways (associated with filament stretching), where stretchiness of mucus sputum in situ is vital, with clinical focus on chronic obstructive pulmonary disease (COPD/sputum); and (ii) bile flow in the biliary system (contraction flow), with clinical focus on disorders of primary sclerosis cholangitis and common bile duct narrowing. Both sputum and bile biofluid systems are represented through kinetic theory rheological fluid modelling, with capability to represent material structure entanglement, branching and anisotropy. This is practically achieved by appealing to the class of pom-pom differential constitutive models, extracted from polymer melt physics and deployed here through a single extended pom-pom (SXPP) approximation. This class of models is sufficiently rich to enable description of both network structure and rheological properties, exhibiting viscoelastic response (memory), with strain-hardening/softening and shear-thinning properties. Springer-Verlag Berlin Heidelberg, 2014 CFD biorheology nationallicence Contraction flows nationallicence Bile duct disorders nationallicence Filament stretching nationallicence Respiratory disorders COPD nationallicence Sputum nationallicence López-Aguilar Jose INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut Webster Michael INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut Al-Muslimawi Alaa INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut Tamaddon-Jahromi Hamid INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut Williams Rhodri INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut Hawkins Karl College of Medicine, Swansea University, SA28PP, Swansea, UK aut Askill Colin College of Medicine, Swansea University, SA28PP, Swansea, UK aut Ch'ng Chin College of Medicine, Swansea University, SA28PP, Swansea, UK aut Davies Gwyneth College of Medicine, Swansea University, SA28PP, Swansea, UK aut Ebden Phillip College of Medicine, Swansea University, SA28PP, Swansea, UK aut Lewis Keir College of Medicine, Swansea University, SA28PP, Swansea, UK aut Rheologica Acta Springer Berlin Heidelberg 54/4(2015-04-01), 287-305 0035-4511 54:4<287 2015 54 397 https://doi.org/10.1007/s00397-014-0830-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00397-014-0830-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- López-Aguilar Jose INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Webster Michael INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Al-Muslimawi Alaa INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Tamaddon-Jahromi Hamid INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Williams Rhodri INNFM, College of Engineering, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Hawkins Karl College of Medicine, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Askill Colin College of Medicine, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Ch'ng Chin College of Medicine, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Davies Gwyneth College of Medicine, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Ebden Phillip College of Medicine, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 700 1- Lewis Keir College of Medicine, Swansea University, SA28PP, Swansea, UK aut NATIONALLICENCE 773 0- Rheologica Acta Springer Berlin Heidelberg 54/4(2015-04-01), 287-305 0035-4511 54:4<287 2015 54 397