caa a22 4500 605476217 CHVBK 20210128100355.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10985-015-9318-z doi (NATIONALLICENCE)springer-10.1007/s10985-015-9318-z A competing risks approach to "biologic” interaction [Elektronische Daten] [Per Andersen, Anders Skrondal] In epidemiology, the concepts of "biologic” and "statistical” interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas. Springer Science+Business Media New York, 2015 Additive rate model nationallicence Competing risks nationallicence Interaction nationallicence Monotonicity nationallicence Necessary and sufficient causes nationallicence Regression model nationallicence Andersen Per Department of Biostatistics, University of Copenhagen, O. Farimagsgade 5, PB2099, 1014, Copenhagen K, Denmark aut Skrondal Anders Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway aut Lifetime Data Analysis Springer US; http://www.springer-ny.com 21/2(2015-04-01), 300-314 1380-7870 21:2<300 2015 21 10985 https://doi.org/10.1007/s10985-015-9318-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10985-015-9318-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andersen Per Department of Biostatistics, University of Copenhagen, O. Farimagsgade 5, PB2099, 1014, Copenhagen K, Denmark aut NATIONALLICENCE 700 1- Skrondal Anders Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway aut NATIONALLICENCE 773 0- Lifetime Data Analysis Springer US; http://www.springer-ny.com 21/2(2015-04-01), 300-314 1380-7870 21:2<300 2015 21 10985