caa a22 4500 605476306 CHVBK 20210128100355.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00787-014-0625-9 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0625-9 Development of children born to mothers with mental health problems: subcortical volumes and cognitive performance at 4½years [Elektronische Daten] [Astrid Bjørnebekk, Torill Siqveland, Kristin Haabrekke, Vibeke Moe, Kari Slinning, Anders Fjell, Kristine Walhovd] In a prospective longitudinal study, we investigated the outcomes of children born to mothers clinically referred for mental health problems during pregnancy (risk group, n=17) relative to a control group (n=31). Child cognitive functioning, and for subgroups (n=10+17), brain morphometry as derived from Magnetic resonance imaging (MRI), was measured at 4½years. Cognitive data included abstract visuospatial reasoning/problem solving and verbal scores. Subcortical regions of interest included the amygdala, accumbens area, hippocampus, caudate and putamen, chosen because their development seems potentially sensitive to an adverse intrauterine milieu and environmental experiences, and also due to their implication in cognitive and emotional processes. The risk group exhibited poorer abstract reasoning scores than the control group. No differences were found for verbal scores. MRI revealed smaller putamen volume in children in the risk group. Irrespective of group, putamen volume was positively related to visuospatial reasoning performance. Our results suggest that maternal psychopathology may be associated with child putamen development, nonverbal reasoning and problem solving skills. Springer-Verlag Berlin Heidelberg, 2014 Maternal psychopathology nationallicence Neuroimaging nationallicence Cognitive development nationallicence Brain morphology nationallicence Abstract reasoning nationallicence Putamen nationallicence Bjørnebekk Astrid Department of Psychology, Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway aut Siqveland Torill Department of Psychology, University of Oslo, Oslo, Norway aut Haabrekke Kristin Department of Psychology, University of Oslo, Oslo, Norway aut Moe Vibeke Department of Psychology, University of Oslo, Oslo, Norway aut Slinning Kari Department of Psychology, University of Oslo, Oslo, Norway aut Fjell Anders Department of Psychology, Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway aut Walhovd Kristine Department of Psychology, Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/1(2015-01-01), 115-118 1018-8827 24:1<115 2015 24 787 https://doi.org/10.1007/s00787-014-0625-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0625-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bjørnebekk Astrid Department of Psychology, Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Siqveland Torill Department of Psychology, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Haabrekke Kristin Department of Psychology, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Moe Vibeke Department of Psychology, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Slinning Kari Department of Psychology, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Fjell Anders Department of Psychology, Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Walhovd Kristine Department of Psychology, Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/1(2015-01-01), 115-118 1018-8827 24:1<115 2015 24 787