Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD
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| 024 | 7 | 0 | |a 10.1007/s00787-014-0533-z |2 doi |
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| 245 | 0 | 0 | |a Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD |h [Elektronische Daten] |c [Halina Kadziela-Olech, Piotr Cichocki, Justyna Chwiesko, Jerzy Konstantynowicz, Jan Braszko] |
| 520 | 3 | |a The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (β=0.33; p=0.043) and HKD (β=0.34, p=0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β=0.38; p=0.019). | |
| 540 | |a The Author(s), 2014 | ||
| 690 | 7 | |a ADHD |2 nationallicence | |
| 690 | 7 | |a HKD |2 nationallicence | |
| 690 | 7 | |a Cognitive |2 nationallicence | |
| 690 | 7 | |a Behaviours |2 nationallicence | |
| 690 | 7 | |a MMP-9 |2 nationallicence | |
| 690 | 7 | |a Boys |2 nationallicence | |
| 700 | 1 | |a Kadziela-Olech |D Halina |u Medical University, Bialystok, Podlaskie, Poland |4 aut | |
| 700 | 1 | |a Cichocki |D Piotr |u Medical University, Bialystok, Podlaskie, Poland |4 aut | |
| 700 | 1 | |a Chwiesko |D Justyna |u Medical University, Bialystok, Podlaskie, Poland |4 aut | |
| 700 | 1 | |a Konstantynowicz |D Jerzy |u Medical University, Bialystok, Podlaskie, Poland |4 aut | |
| 700 | 1 | |a Braszko |D Jan |u Medical University, Bialystok, Podlaskie, Poland |4 aut | |
| 773 | 0 | |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/1(2015-01-01), 55-63 |x 1018-8827 |q 24:1<55 |1 2015 |2 24 |o 787 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00787-014-0533-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00787-014-0533-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kadziela-Olech |D Halina |u Medical University, Bialystok, Podlaskie, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cichocki |D Piotr |u Medical University, Bialystok, Podlaskie, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chwiesko |D Justyna |u Medical University, Bialystok, Podlaskie, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Konstantynowicz |D Jerzy |u Medical University, Bialystok, Podlaskie, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Braszko |D Jan |u Medical University, Bialystok, Podlaskie, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/1(2015-01-01), 55-63 |x 1018-8827 |q 24:1<55 |1 2015 |2 24 |o 787 | ||