caa a22 4500 605476365 CHVBK 20210128100356.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00787-014-0533-z doi (NATIONALLICENCE)springer-10.1007/s00787-014-0533-z Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD [Elektronische Daten] [Halina Kadziela-Olech, Piotr Cichocki, Justyna Chwiesko, Jerzy Konstantynowicz, Jan Braszko] The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7-12years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (β=0.33; p=0.043) and HKD (β=0.34, p=0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β=0.38; p=0.019). The Author(s), 2014 ADHD nationallicence HKD nationallicence Cognitive nationallicence Behaviours nationallicence MMP-9 nationallicence Boys nationallicence Kadziela-Olech Halina Medical University, Bialystok, Podlaskie, Poland aut Cichocki Piotr Medical University, Bialystok, Podlaskie, Poland aut Chwiesko Justyna Medical University, Bialystok, Podlaskie, Poland aut Konstantynowicz Jerzy Medical University, Bialystok, Podlaskie, Poland aut Braszko Jan Medical University, Bialystok, Podlaskie, Poland aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/1(2015-01-01), 55-63 1018-8827 24:1<55 2015 24 787 https://doi.org/10.1007/s00787-014-0533-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0533-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kadziela-Olech Halina Medical University, Bialystok, Podlaskie, Poland aut NATIONALLICENCE 700 1- Cichocki Piotr Medical University, Bialystok, Podlaskie, Poland aut NATIONALLICENCE 700 1- Chwiesko Justyna Medical University, Bialystok, Podlaskie, Poland aut NATIONALLICENCE 700 1- Konstantynowicz Jerzy Medical University, Bialystok, Podlaskie, Poland aut NATIONALLICENCE 700 1- Braszko Jan Medical University, Bialystok, Podlaskie, Poland aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/1(2015-01-01), 55-63 1018-8827 24:1<55 2015 24 787