caa a22 4500 605476500 CHVBK 20210128100356.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00787-015-0702-8 doi (NATIONALLICENCE)springer-10.1007/s00787-015-0702-8 Genetics in child and adolescent psychiatry: methodological advances and conceptual issues [Elektronische Daten] [Sarah Hohmann, Nicoletta Adamo, Benjamin Lahey, Stephen Faraone, Tobias Banaschewski] Discovering the genetic basis of early-onset psychiatric disorders has been the aim of intensive research during the last decade. We will first selectively summarize results of genetic research in child and adolescent psychiatry by using examples from different disorders and discuss methodological issues, emerging questions and future directions. In the second part of this review, we will focus on how to link genetic causes of disorders with physiological pathways, discuss the impact of genetic findings on diagnostic systems, prevention and therapeutic interventions. Finally we will highlight some ethical aspects connected to genetic research in child and adolescent psychiatry. Advances in molecular genetic methods have led to insights into the genetic architecture of psychiatric disorders, but not yet provided definite pathways to pathophysiology. If replicated, promising findings from genetic studies might in some cases lead to personalized treatments. On the one hand, knowledge of the genetic basis of disorders may influence diagnostic categories. On the other hand, models also suggest studying the genetic architecture of psychiatric disorders across diagnoses and clinical groups. Springer-Verlag Berlin Heidelberg, 2015 Gene-environment interactions nationallicence Neurodevelopmental disorders nationallicence Copy number variations nationallicence Genome-wide association studies nationallicence Taxonomy nationallicence Hohmann Sarah Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany aut Adamo Nicoletta Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany aut Lahey Benjamin Departments of Health Studies and Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA aut Faraone Stephen Department of Psychiatry and Behavioral Sciences, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, USA aut Banaschewski Tobias Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/6(2015-06-01), 619-634 1018-8827 24:6<619 2015 24 787 https://doi.org/10.1007/s00787-015-0702-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-015-0702-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hohmann Sarah Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany aut NATIONALLICENCE 700 1- Adamo Nicoletta Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany aut NATIONALLICENCE 700 1- Lahey Benjamin Departments of Health Studies and Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA aut NATIONALLICENCE 700 1- Faraone Stephen Department of Psychiatry and Behavioral Sciences, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, USA aut NATIONALLICENCE 700 1- Banaschewski Tobias Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/6(2015-06-01), 619-634 1018-8827 24:6<619 2015 24 787