caa a22 4500 605476594 CHVBK 20210128100357.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00787-014-0651-7 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0651-7 The association between prenatal environment and children's mental health trajectories from 2 to 14years [Elektronische Daten] [Jessica Tearne, Karina Allen, Carly Herbison, David Lawrence, Andrew Whitehouse, Michael Sawyer, Monique Robinson] The prenatal period is recognised as a critical period for later behavioural development. This study aimed to elucidate how an adverse prenatal environment, as defined by the presence of a number of known prenatal risk factors, would influence mental health trajectories in children to 14years of age. The Raine Study provided comprehensive data from 2,900 pregnancies. Offspring were followed up at ages 2, 5, 8, 10, and 14years using the Child Behaviour Checklist (CBCL). We used linear mixed regression models with random intercept and slope (random effects models) to examine the extent to which the predictor variables considered influenced changes in continuous CBCL total, internalising, and externalising T scores from ages 2 to 14. In the final multivariate models, increased offspring CBCL T scores were significantly predicted by the mother not finishing high school, smoking during pregnancy, having a total family income below the poverty line, being diagnosed with gestational hypertension and experiencing stressful life events during pregnancy. Conversely, as maternal age increased, CBCL T scores were significantly decreased. Child age also significantly interacted with maternal education, total family income, and maternal stressful life events, such that these variables predicted increases in CBCL scores from age 2 to age 10, and from age 2 to age 14years. In the Raine Study sample, children who experienced adverse prenatal environments experienced increased levels of problem behaviours in childhood, and more problematic mental health trajectories. Maternal health risk behaviours and other psychosocial variables more commonly affected child behaviour than obstetric complications. Springer-Verlag Berlin Heidelberg, 2014 Mental health nationallicence Behaviour nationallicence Trajectories nationallicence Longitudinal cohort study nationallicence Raine Study nationallicence Tearne Jessica Telethon Kids Institute, The University of Western Australia, Perth, Australia aut Allen Karina Telethon Kids Institute, The University of Western Australia, Perth, Australia aut Herbison Carly Telethon Kids Institute, The University of Western Australia, Perth, Australia aut Lawrence David Telethon Kids Institute, The University of Western Australia, Perth, Australia aut Whitehouse Andrew Telethon Kids Institute, The University of Western Australia, Perth, Australia aut Sawyer Michael School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, Australia aut Robinson Monique Telethon Kids Institute, The University of Western Australia, Perth, Australia aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/9(2015-09-01), 1015-1024 1018-8827 24:9<1015 2015 24 787 https://doi.org/10.1007/s00787-014-0651-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0651-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tearne Jessica Telethon Kids Institute, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Allen Karina Telethon Kids Institute, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Herbison Carly Telethon Kids Institute, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Lawrence David Telethon Kids Institute, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Whitehouse Andrew Telethon Kids Institute, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Sawyer Michael School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, Australia aut NATIONALLICENCE 700 1- Robinson Monique Telethon Kids Institute, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/9(2015-09-01), 1015-1024 1018-8827 24:9<1015 2015 24 787