Sex-specific and time-dependent effects of prenatal stress on the early behavioral symptoms of ADHD: a longitudinal study in China
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| 024 | 7 | 0 | |a 10.1007/s00787-015-0701-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00787-015-0701-9 | ||
| 245 | 0 | 0 | |a Sex-specific and time-dependent effects of prenatal stress on the early behavioral symptoms of ADHD: a longitudinal study in China |h [Elektronische Daten] |c [Peng Zhu, Jia-Hu Hao, Rui-Xue Tao, Kun Huang, Xiao-Min Jiang, Yuan-Duo Zhu, Fang-Biao Tao] |
| 520 | 3 | |a There is increasing evidence that prenatal stressful life events (SLEs) may be a potential risk factor for attention-deficit hyperactivity disorder (ADHD), but the sex-specific and time-dependent effects of prenatal stress on ADHD are less clear. In this prospective longitudinal study, data on prenatal SLEs during different stages of gestation and indicators of buffers against stress, including maternal social support and avoidance coping, were obtained from 1765 pregnant women at 32weeks of gestation. The behavioral symptoms of ADHD in children aged 48-54months were evaluated by reports from the parents. There were 226 children (12.8%) above the clinically significant cutoff for ADHD. After adjusting for potential confounders, boys whose mother experienced severe SLEs in the second trimester had a significantly increased risk (OR=2.41, 95% CI: 1.03-5.66) of developing ADHD symptoms compared with boys whose mothers did not experience severe SLEs at this time. However, no significantly increased risk of ADHD symptoms was observed in girls born to mothers experienced prenatal severe SLEs. Additionally, significant interaction effects of prenatal SLEs, social support and coping style on ADHD symptoms were found in males. Boys whose mothers experienced severe SLEs during the second trimester accompanied by a higher score for avoidance coping (OR=3.31, 95% CI: 1.13-9.70) or a lower score for social support (OR=4.39, 95% CI: 1.05-18.31) were likely to be at a higher risk for ADHD symptoms. The epidemiological evidence in this prospective follow-up study suggests that the effect of prenatal SLEs on ADHD symptoms in offspring may depend on the timing of prenatal stress and may vary according to the sex of the offspring. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Attention-deficit hyperactivity disorder (ADHD) |2 nationallicence | |
| 690 | 7 | |a Pregnancy |2 nationallicence | |
| 690 | 7 | |a Prenatal stress |2 nationallicence | |
| 690 | 7 | |a Life events |2 nationallicence | |
| 690 | 7 | |a Social support |2 nationallicence | |
| 690 | 7 | |a Coping style |2 nationallicence | |
| 690 | 7 | |a Longitudinal |2 nationallicence | |
| 690 | 7 | |a ADHD : Attention-deficit hyperactivity disorder |2 nationallicence | |
| 690 | 7 | |a BMI : Body mass index |2 nationallicence | |
| 690 | 7 | |a PNMS : Prenatal maternal stress |2 nationallicence | |
| 690 | 7 | |a SLEs : Stressful life events |2 nationallicence | |
| 700 | 1 | |a Zhu |D Peng |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | |
| 700 | 1 | |a Hao |D Jia-Hu |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | |
| 700 | 1 | |a Tao |D Rui-Xue |u Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei, Anhui, China |4 aut | |
| 700 | 1 | |a Huang |D Kun |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | |
| 700 | 1 | |a Jiang |D Xiao-Min |u Department of Gynecology and Obstetrics, Hefei Maternal and Child Health Hospital, Hefei, Anhui, China |4 aut | |
| 700 | 1 | |a Zhu |D Yuan-Duo |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | |
| 700 | 1 | |a Tao |D Fang-Biao |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | |
| 773 | 0 | |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/9(2015-09-01), 1139-1147 |x 1018-8827 |q 24:9<1139 |1 2015 |2 24 |o 787 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00787-015-0701-9 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00787-015-0701-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhu |D Peng |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hao |D Jia-Hu |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tao |D Rui-Xue |u Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei, Anhui, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huang |D Kun |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jiang |D Xiao-Min |u Department of Gynecology and Obstetrics, Hefei Maternal and Child Health Hospital, Hefei, Anhui, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhu |D Yuan-Duo |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tao |D Fang-Biao |u Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/9(2015-09-01), 1139-1147 |x 1018-8827 |q 24:9<1139 |1 2015 |2 24 |o 787 | ||