caa a22 4500 605476675 CHVBK 20210128100357.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00787-015-0701-9 doi (NATIONALLICENCE)springer-10.1007/s00787-015-0701-9 Sex-specific and time-dependent effects of prenatal stress on the early behavioral symptoms of ADHD: a longitudinal study in China [Elektronische Daten] [Peng Zhu, Jia-Hu Hao, Rui-Xue Tao, Kun Huang, Xiao-Min Jiang, Yuan-Duo Zhu, Fang-Biao Tao] There is increasing evidence that prenatal stressful life events (SLEs) may be a potential risk factor for attention-deficit hyperactivity disorder (ADHD), but the sex-specific and time-dependent effects of prenatal stress on ADHD are less clear. In this prospective longitudinal study, data on prenatal SLEs during different stages of gestation and indicators of buffers against stress, including maternal social support and avoidance coping, were obtained from 1765 pregnant women at 32weeks of gestation. The behavioral symptoms of ADHD in children aged 48-54months were evaluated by reports from the parents. There were 226 children (12.8%) above the clinically significant cutoff for ADHD. After adjusting for potential confounders, boys whose mother experienced severe SLEs in the second trimester had a significantly increased risk (OR=2.41, 95% CI: 1.03-5.66) of developing ADHD symptoms compared with boys whose mothers did not experience severe SLEs at this time. However, no significantly increased risk of ADHD symptoms was observed in girls born to mothers experienced prenatal severe SLEs. Additionally, significant interaction effects of prenatal SLEs, social support and coping style on ADHD symptoms were found in males. Boys whose mothers experienced severe SLEs during the second trimester accompanied by a higher score for avoidance coping (OR=3.31, 95% CI: 1.13-9.70) or a lower score for social support (OR=4.39, 95% CI: 1.05-18.31) were likely to be at a higher risk for ADHD symptoms. The epidemiological evidence in this prospective follow-up study suggests that the effect of prenatal SLEs on ADHD symptoms in offspring may depend on the timing of prenatal stress and may vary according to the sex of the offspring. Springer-Verlag Berlin Heidelberg, 2015 Attention-deficit hyperactivity disorder (ADHD) nationallicence Pregnancy nationallicence Prenatal stress nationallicence Life events nationallicence Social support nationallicence Coping style nationallicence Longitudinal nationallicence ADHD : Attention-deficit hyperactivity disorder nationallicence BMI : Body mass index nationallicence PNMS : Prenatal maternal stress nationallicence SLEs : Stressful life events nationallicence Zhu Peng Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut Hao Jia-Hu Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut Tao Rui-Xue Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei, Anhui, China aut Huang Kun Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut Jiang Xiao-Min Department of Gynecology and Obstetrics, Hefei Maternal and Child Health Hospital, Hefei, Anhui, China aut Zhu Yuan-Duo Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut Tao Fang-Biao Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/9(2015-09-01), 1139-1147 1018-8827 24:9<1139 2015 24 787 https://doi.org/10.1007/s00787-015-0701-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-015-0701-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Peng Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Hao Jia-Hu Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Tao Rui-Xue Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Huang Kun Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Jiang Xiao-Min Department of Gynecology and Obstetrics, Hefei Maternal and Child Health Hospital, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Zhu Yuan-Duo Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Tao Fang-Biao Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal and Child Health, Anhui Medical University, 81 Mei Shan Road, 230032, Hefei, Anhui, China aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/9(2015-09-01), 1139-1147 1018-8827 24:9<1139 2015 24 787