caa a22 4500 605476802 CHVBK 20210128100358.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00787-014-0627-7 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0627-7 GRIN2B predicts attention problems among disadvantaged children [Elektronische Daten] [Valentina Riva, Marco Battaglia, Maria Nobile, Francesca Cattaneo, Claudio Lazazzera, Sara Mascheretti, Roberto Giorda, Chantal Mérette, Claudia Émond, Michel Maziade, Cecilia Marino] It is well established that adversities and GRIN2B (coding an N-methyl-d-aspartate receptor subunit) are independently associated with behavioral and cognitive impairments in childhood. However, a high proportion of children exposed to adversities have good, long-term outcomes. We hypothesized that among children exposed to adversities, GRIN2B variants would predict the worst cognitive and behavioral outcomes. 6 single nucleotide polymorphisms of GRIN2B were genotyped in 625 children aged 6-11years from an Italian community-based sample. The interacting effect of GRIN2B variants with 4 measures of adversities [low socioeconomic status (SES), preterm delivery, maternal smoking during pregnancy, and absence of breastfeeding] was investigated upon blindly assessed cognitive abilities (vocabulary, block design, digit spans of Wechsler's Intelligence Scale, and Rey complex figure) and parents-rated behavioral problems (Child Behavior Checklist/6-18). Rs2268119×SES interaction (Hotelling's Trace=0.07; F(12,1154)=3.53; p=0.00004) influenced behavior, with more attention problems among children in the ‘either A/T or T/T genotype and low SES' group, compared to all other groups. This interaction effect was not significant in an independent, replication sample of 475 subjects from an Italian community-based sample. GRIN2B variants predict children with the worst outcome in attention functioning among children exposed to low SES. Our findings, if replicated, could help in the identification of children with the highest risk and may prompt cost-effective preventive/treatment strategies. Springer-Verlag Berlin Heidelberg, 2014 Socioeconomic status nationallicence GRIN2B nationallicence Gene-environment interaction nationallicence Riva Valentina Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut Battaglia Marco Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut Nobile Maria Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut Cattaneo Francesca Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut Lazazzera Claudio Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut Mascheretti Sara Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut Giorda Roberto Molecular Biology Laboratory, Scientific Institute ‘Eugenio Medea', Don L Monza 20, Bosisio Parini (LC), Italy aut Mérette Chantal Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut Émond Claudia Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut Maziade Michel Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut Marino Cecilia Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/7(2015-07-01), 827-836 1018-8827 24:7<827 2015 24 787 https://doi.org/10.1007/s00787-014-0627-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0627-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Riva Valentina Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut NATIONALLICENCE 700 1- Battaglia Marco Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut NATIONALLICENCE 700 1- Nobile Maria Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut NATIONALLICENCE 700 1- Cattaneo Francesca Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut NATIONALLICENCE 700 1- Lazazzera Claudio Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut NATIONALLICENCE 700 1- Mascheretti Sara Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut NATIONALLICENCE 700 1- Giorda Roberto Molecular Biology Laboratory, Scientific Institute ‘Eugenio Medea', Don L Monza 20, Bosisio Parini (LC), Italy aut NATIONALLICENCE 700 1- Mérette Chantal Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut NATIONALLICENCE 700 1- Émond Claudia Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut NATIONALLICENCE 700 1- Maziade Michel Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, 2601 Chemin de la Canardière, Quebec, Canada aut NATIONALLICENCE 700 1- Marino Cecilia Child Psychopathology Unit, Scientific Institute ‘Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/7(2015-07-01), 827-836 1018-8827 24:7<827 2015 24 787