caa a22 4500 605476837 CHVBK 20210128100358.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00787-015-0765-6 doi (NATIONALLICENCE)springer-10.1007/s00787-015-0765-6 Salivary oxytocin in adolescents with conduct problems and callous-unemotional traits [Elektronische Daten] [Tomer Levy, Yuval Bloch, Meytal Bar-Maisels, Galia Gat-Yablonski, Amir Djalovski, Katy Borodkin, Alan Apter] Callous-unemotional (CU) traits correlate with the severity and prognosis of conduct disorder in youth. The neuropeptide oxytocin (OT) has been linked to prosocial behaviors, including empathy and collaboration with others. This study discusses a possible role for OT in the biology of delinquent behavior. We hypothesized that in delinquent youth OT secretion will correlate with the severity of conduct problems and specifically with the level of CU traits. The study group included 67 male adolescents (mean age 16.2years) undergoing residential treatment, previously assessed by an open clinical interview and history for the psychiatric diagnosis. Staff based Inventory of Callous-Unemotional traits for psychopathy and Strength and Difficulties Questionnaire were administered, and patients' medical and social personal files were systematically coded for previous history of antisocial acts using the Brown-Goodwin Questionnaire. Salivary OT was assayed by ELISA. Salivary OT levels were inversely correlated with conduct problems severity on Strength and Difficulties Questionnaire (r=−0.27; p≤0.01). Recorded history of antisocial acts did not correlate with current OT levels. Odds ratio (OR) for significant CU traits among subjects with conduct problems was increased in low-OT (OR=14, p≤0.05) but not in high-OT subjects (OR=6, p≥0.05). Children with conduct problems and low levels of salivary OT are at risk for significant CU traits. These results suggest a possible role for salivary OT as a biomarker for CU traits and conduct problems severity. Springer-Verlag Berlin Heidelberg, 2015 Oxytocin nationallicence Conduct Disorder nationallicence Psychopathy nationallicence Callous-Unemotional traits, adolescents nationallicence BGQ : Brown Goodwin questionnaire nationallicence CD : Conduct disorder nationallicence CP : Conduct problems nationallicence CU : Callous-unemotional nationallicence ICU : Inventory of callous-unemotional traits nationallicence OT : Oxytocin nationallicence OXTR : Oxytocin receptor nationallicence SDQ : Strength and difficulties questionnaire nationallicence SNP : Single nucleotide polymorphism nationallicence Levy Tomer Department of Child and Adolescent Psychiatry, Shalvata Mental Health Center, 45100, Hod Hasharon, Israel aut Bloch Yuval Department of Child and Adolescent Psychiatry, Shalvata Mental Health Center, 45100, Hod Hasharon, Israel aut Bar-Maisels Meytal Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut Gat-Yablonski Galia Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut Djalovski Amir Department of Psychology and The Gonda Brain Sciences Center, Bar-Ilan University, 52900, Ramat-Gan, Israel aut Borodkin Katy Speech-Language-Hearing Sciences, Lehman College, The City University of New York, 10468, New York, NY, USA aut Apter Alan Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/12(2015-12-01), 1543-1551 1018-8827 24:12<1543 2015 24 787 https://doi.org/10.1007/s00787-015-0765-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-015-0765-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levy Tomer Department of Child and Adolescent Psychiatry, Shalvata Mental Health Center, 45100, Hod Hasharon, Israel aut NATIONALLICENCE 700 1- Bloch Yuval Department of Child and Adolescent Psychiatry, Shalvata Mental Health Center, 45100, Hod Hasharon, Israel aut NATIONALLICENCE 700 1- Bar-Maisels Meytal Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Gat-Yablonski Galia Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Djalovski Amir Department of Psychology and The Gonda Brain Sciences Center, Bar-Ilan University, 52900, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Borodkin Katy Speech-Language-Hearing Sciences, Lehman College, The City University of New York, 10468, New York, NY, USA aut NATIONALLICENCE 700 1- Apter Alan Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/12(2015-12-01), 1543-1551 1018-8827 24:12<1543 2015 24 787