caa a22 4500 605476845 CHVBK 20210128100358.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00787-015-0693-5 doi (NATIONALLICENCE)springer-10.1007/s00787-015-0693-5 Functional deterioration from the premorbid period to 2 years after the first episode of psychosis in early-onset psychosis [Elektronische Daten] [Ángel Del Rey-Mejías, David Fraguas, Covadonga Díaz-Caneja, Laura Pina-Camacho, Josefina Castro-Fornieles, Inmaculada Baeza, Ana Espliego, Jessica Merchán-Naranjo, Ana González-Pinto, Elena de la Serna, Beatriz Payá, Montserrat Graell, Celso Arango, Mara Parellada] The aim of the study was to analyze changes in functional adjustment from childhood to 2years after the first episode of psychosis (FEP) in patients with early-onset schizophrenia spectrum disorders (SSD) and affective psychoses (AFP) and a good or intermediate level of premorbid adjustment. We followed 106 adolescents (aged 12-17years) with FEP for 2years after recruitment. Premorbid adjustment in childhood was assessed in 98 patients with the childhood subscale of the Cannon-Spoor Premorbid Adjustment Scale (c-PAS). Global functioning was assessed 2years after the FEP with the Children's Global Assessment Scale (c-GAS) or the Global Assessment of Functioning scale (GAF), as appropriate. Functional deterioration was defined as a downward shift in the level of functional adjustment from childhood to 2 years after the FEP. In patients with good or intermediate premorbid adjustment, functional deterioration was observed in 28.2% (26.5% of the AFP group, 29.4% of the SSD group). Longer duration of untreated psychosis (Beta=0.01; P=0.01) and higher symptom severity at the FEP, as measured with the Clinical Global Impression Scale (Beta=1.12; P=0.02), significantly predicted the presence of functional deterioration, accounting for 21.4% of the variance. Irrespective of diagnosis (SSD or AFP), almost one-third of adolescents with FEP and good or intermediate premorbid adjustment showed functional deterioration from the premorbid period to 2years after the FEP. Springer-Verlag Berlin Heidelberg, 2015 Premorbid adjustment nationallicence Global functioning nationallicence Duration of untreated psychosis nationallicence First-episode psychosis nationallicence Schizophrenia nationallicence Affective psychosis nationallicence Early-onset psychosis nationallicence Del Rey-Mejías Ángel Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Fraguas David Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Díaz-Caneja Covadonga Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Pina-Camacho Laura Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Castro-Fornieles Josefina Department of Child and Adolescent Psychiatry and Psychology, SGR-489CIBERSAM. Institute Clinic of Neurosciences, IDIBAPS, Hospital Clinic of Barcelona, Barcelona, Spain aut Baeza Inmaculada Department of Child and Adolescent Psychiatry and Psychology, SGR-489CIBERSAM. Institute Clinic of Neurosciences, IDIBAPS, Hospital Clinic of Barcelona, Barcelona, Spain aut Espliego Ana Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Merchán-Naranjo Jessica Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut González-Pinto Ana Mood Disorders Research Center, 03-RC-003, Hospital Santiago Apóstol, CIBERSAM, Vitoria, Spain aut de la Serna Elena Department of Child and Adolescent Psychiatry and Psychology, SGR-489CIBERSAM. Institute Clinic of Neurosciences, IDIBAPS, Hospital Clinic of Barcelona, Barcelona, Spain aut Payá Beatriz Department of Child Psychiatry, Hospital Universitario Marqués de Valdecilla, CIBERSAM, Santander, Spain aut Graell Montserrat Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesus, CIBERSAM, Madrid, Spain aut Arango Celso Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Parellada Mara Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/12(2015-12-01), 1447-1459 1018-8827 24:12<1447 2015 24 787 https://doi.org/10.1007/s00787-015-0693-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-015-0693-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Del Rey-Mejías Ángel Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Fraguas David Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Díaz-Caneja Covadonga Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Pina-Camacho Laura Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Castro-Fornieles Josefina Department of Child and Adolescent Psychiatry and Psychology, SGR-489CIBERSAM. Institute Clinic of Neurosciences, IDIBAPS, Hospital Clinic of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Baeza Inmaculada Department of Child and Adolescent Psychiatry and Psychology, SGR-489CIBERSAM. Institute Clinic of Neurosciences, IDIBAPS, Hospital Clinic of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Espliego Ana Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Merchán-Naranjo Jessica Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- González-Pinto Ana Mood Disorders Research Center, 03-RC-003, Hospital Santiago Apóstol, CIBERSAM, Vitoria, Spain aut NATIONALLICENCE 700 1- de la Serna Elena Department of Child and Adolescent Psychiatry and Psychology, SGR-489CIBERSAM. Institute Clinic of Neurosciences, IDIBAPS, Hospital Clinic of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Payá Beatriz Department of Child Psychiatry, Hospital Universitario Marqués de Valdecilla, CIBERSAM, Santander, Spain aut NATIONALLICENCE 700 1- Graell Montserrat Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesus, CIBERSAM, Madrid, Spain aut NATIONALLICENCE 700 1- Arango Celso Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Parellada Mara Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/12(2015-12-01), 1447-1459 1018-8827 24:12<1447 2015 24 787