caa a22 4500 605476896 CHVBK 20210128100358.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00787-015-0768-3 doi (NATIONALLICENCE)springer-10.1007/s00787-015-0768-3 Psychiatric symptoms in adolescents: FKBP5 genotype—early life adversity interaction effects [Elektronische Daten] [Erika Comasco, Per Gustafsson, Gunilla Sydsjö, Sara Agnafors, Nikolas Aho, Carl Svedin] Psychiatric disorders are multi-factorial and their symptoms overlap. Constitutional and environmental factors influence each other, and this contributes to risk and resilience in mental ill-health. We investigated functional genetic variation of stress responsiveness, assessed as FKBP5 genotype, in relation to early life adversity and mental health in two samples of adolescents. One population-based sample of 909 12-year-old adolescents was assessed using the Life Incidence of Traumatic Events scale and the Strengths and Difficulties Questionnaire. One sample of 398 17-year-old adolescents, enriched for poly-victimized individuals (USSS), was assessed using the Juvenile Victimization Questionnaire and the Trauma Symptom Checklist for Children (TSCC). The FKBP5 rs1360780 and rs3800373 polymorphisms were genotyped using a fluorescence-based competitive allele-specific PCR. Most prominently among poly-victimized older male adolescents, the least common alleles of the polymorphisms, in interaction with adverse life events, were associated with psychiatric symptoms, after controlling for ethno-socio-economic factors. The interaction effect between rs3800373 and adverse life events on the TSCC sub-scales—anxiety, depression, anger, and dissociation—and with the rs1360780 on dissociation in the USSS cohort remained significant after Bonferroni correction. This pattern of association is in line with the findings of clinical and neuroimaging studies, and implies interactive effects of FKBP5 polymorphisms and early life environment on several psychiatric symptoms. These correlates add up to provide constructs that are relevant to several psychiatric symptoms, and to identify early predictors of mental ill-health. Springer-Verlag Berlin Heidelberg, 2015 Adolescents nationallicence FKBP5 nationallicence Gene nationallicence Mental health nationallicence Stress nationallicence Comasco Erika Department of Neuroscience, Uppsala University, Uppsala, Sweden aut Gustafsson Per Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut Sydsjö Gunilla Division of Obstetrics and Gynaecology, Linköping University, Linköping, Sweden aut Agnafors Sara Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut Aho Nikolas Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut Svedin Carl Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/12(2015-12-01), 1473-1483 1018-8827 24:12<1473 2015 24 787 https://doi.org/10.1007/s00787-015-0768-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-015-0768-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Comasco Erika Department of Neuroscience, Uppsala University, Uppsala, Sweden aut NATIONALLICENCE 700 1- Gustafsson Per Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut NATIONALLICENCE 700 1- Sydsjö Gunilla Division of Obstetrics and Gynaecology, Linköping University, Linköping, Sweden aut NATIONALLICENCE 700 1- Agnafors Sara Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut NATIONALLICENCE 700 1- Aho Nikolas Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut NATIONALLICENCE 700 1- Svedin Carl Division of Child and Adolescent Psychiatry, IKE, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/12(2015-12-01), 1473-1483 1018-8827 24:12<1473 2015 24 787