The NeuroIMAGE study: a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder. Design and descriptives

Verfasser / Beitragende:
[Daniel von Rhein, Maarten Mennes, Hanneke van Ewijk, Annabeth Groenman, Marcel Zwiers, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Pieter Hoekstra, Stephen Faraone, Catharina Hartman, Jan Buitelaar]
Ort, Verlag, Jahr:
2015
Enthalten in:
European Child & Adolescent Psychiatry, 24/3(2015-03-01), 265-281
Format:
Artikel (online)
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245 0 4 |a The NeuroIMAGE study: a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder. Design and descriptives  |h [Elektronische Daten]  |c [Daniel von Rhein, Maarten Mennes, Hanneke van Ewijk, Annabeth Groenman, Marcel Zwiers, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Pieter Hoekstra, Stephen Faraone, Catharina Hartman, Jan Buitelaar] 
520 3 |a Attention-deficit/hyperactivity disorder (ADHD) is a persistent neuropsychiatric disorder which is associated with impairments on a variety of cognitive measures and abnormalities in structural and functional brain measures. Genetic factors are thought to play an important role in the etiology of ADHD. The NeuroIMAGE study is a follow-up of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) project. It is a multi-site prospective cohort study designed to investigate the course of ADHD, its genetic and environmental determinants, its cognitive and neurobiological underpinnings, and its consequences in adolescence and adulthood. From the original 365 ADHD families and 148 control (CON) IMAGE families, consisting of 506 participants with an ADHD diagnosis, 350 unaffected siblings, and 283 healthy controls, 79% participated in the NeuroIMAGE follow-up study. Combined with newly recruited participants the NeuroIMAGE study comprehends an assessment of 1,069 children (751 from ADHD families; 318 from CON families) and 848 parents (582 from ADHD families; 266 from CON families). For most families, data for more than one child (82%) and both parents (82%) were available. Collected data include a diagnostic interview, behavioural questionnaires, cognitive measures, structural and functional neuroimaging, and genome-wide genetic information. The NeuroIMAGE dataset allows examining the course of ADHD over adolescence into young adulthood, identifying phenotypic, cognitive, and neural mechanisms associated with the persistence versus remission of ADHD, and studying their genetic and environmental underpinnings. The inclusion of siblings of ADHD probands and controls allows modelling of shared familial influences on the ADHD phenotype. 
540 |a Springer-Verlag Berlin Heidelberg, 2014 
690 7 |a Attention-deficit/hyperactivity disorder  |2 nationallicence 
690 7 |a Cognition  |2 nationallicence 
690 7 |a Imaging  |2 nationallicence 
690 7 |a Genetics  |2 nationallicence 
690 7 |a Development  |2 nationallicence 
690 7 |a Familiality  |2 nationallicence 
700 1 |a von Rhein  |D Daniel  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
700 1 |a Mennes  |D Maarten  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
700 1 |a van Ewijk  |D Hanneke  |u Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands  |4 aut 
700 1 |a Groenman  |D Annabeth  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
700 1 |a Zwiers  |D Marcel  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
700 1 |a Oosterlaan  |D Jaap  |u Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands  |4 aut 
700 1 |a Heslenfeld  |D Dirk  |u Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands  |4 aut 
700 1 |a Franke  |D Barbara  |u Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands  |4 aut 
700 1 |a Hoekstra  |D Pieter  |u Department of Psychiatry, University Medical Center, Groningen, The Netherlands  |4 aut 
700 1 |a Faraone  |D Stephen  |u Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, USA  |4 aut 
700 1 |a Hartman  |D Catharina  |u Department of Psychiatry, University Medical Center, Groningen, The Netherlands  |4 aut 
700 1 |a Buitelaar  |D Jan  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a von Rhein  |D Daniel  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Mennes  |D Maarten  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a van Ewijk  |D Hanneke  |u Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Groenman  |D Annabeth  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Zwiers  |D Marcel  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Oosterlaan  |D Jaap  |u Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Heslenfeld  |D Dirk  |u Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Franke  |D Barbara  |u Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Hoekstra  |D Pieter  |u Department of Psychiatry, University Medical Center, Groningen, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Faraone  |D Stephen  |u Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, USA  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Hartman  |D Catharina  |u Department of Psychiatry, University Medical Center, Groningen, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Buitelaar  |D Jan  |u Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands  |4 aut 
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