caa a22 4500 605476934 CHVBK 20210128100358.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00787-014-0573-4 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0573-4 The NeuroIMAGE study: a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder. Design and descriptives [Elektronische Daten] [Daniel von Rhein, Maarten Mennes, Hanneke van Ewijk, Annabeth Groenman, Marcel Zwiers, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Pieter Hoekstra, Stephen Faraone, Catharina Hartman, Jan Buitelaar] Attention-deficit/hyperactivity disorder (ADHD) is a persistent neuropsychiatric disorder which is associated with impairments on a variety of cognitive measures and abnormalities in structural and functional brain measures. Genetic factors are thought to play an important role in the etiology of ADHD. The NeuroIMAGE study is a follow-up of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) project. It is a multi-site prospective cohort study designed to investigate the course of ADHD, its genetic and environmental determinants, its cognitive and neurobiological underpinnings, and its consequences in adolescence and adulthood. From the original 365 ADHD families and 148 control (CON) IMAGE families, consisting of 506 participants with an ADHD diagnosis, 350 unaffected siblings, and 283 healthy controls, 79% participated in the NeuroIMAGE follow-up study. Combined with newly recruited participants the NeuroIMAGE study comprehends an assessment of 1,069 children (751 from ADHD families; 318 from CON families) and 848 parents (582 from ADHD families; 266 from CON families). For most families, data for more than one child (82%) and both parents (82%) were available. Collected data include a diagnostic interview, behavioural questionnaires, cognitive measures, structural and functional neuroimaging, and genome-wide genetic information. The NeuroIMAGE dataset allows examining the course of ADHD over adolescence into young adulthood, identifying phenotypic, cognitive, and neural mechanisms associated with the persistence versus remission of ADHD, and studying their genetic and environmental underpinnings. The inclusion of siblings of ADHD probands and controls allows modelling of shared familial influences on the ADHD phenotype. Springer-Verlag Berlin Heidelberg, 2014 Attention-deficit/hyperactivity disorder nationallicence Cognition nationallicence Imaging nationallicence Genetics nationallicence Development nationallicence Familiality nationallicence von Rhein Daniel Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut Mennes Maarten Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut van Ewijk Hanneke Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands aut Groenman Annabeth Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut Zwiers Marcel Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut Oosterlaan Jaap Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands aut Heslenfeld Dirk Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands aut Franke Barbara Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands aut Hoekstra Pieter Department of Psychiatry, University Medical Center, Groningen, The Netherlands aut Faraone Stephen Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, USA aut Hartman Catharina Department of Psychiatry, University Medical Center, Groningen, The Netherlands aut Buitelaar Jan Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/3(2015-03-01), 265-281 1018-8827 24:3<265 2015 24 787 https://doi.org/10.1007/s00787-014-0573-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0573-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- von Rhein Daniel Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Mennes Maarten Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- van Ewijk Hanneke Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Groenman Annabeth Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Zwiers Marcel Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Oosterlaan Jaap Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Heslenfeld Dirk Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Franke Barbara Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Hoekstra Pieter Department of Psychiatry, University Medical Center, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Faraone Stephen Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, USA aut NATIONALLICENCE 700 1- Hartman Catharina Department of Psychiatry, University Medical Center, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Buitelaar Jan Centre for Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/3(2015-03-01), 265-281 1018-8827 24:3<265 2015 24 787