caa a22 4500 605477019 CHVBK 20210128100359.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00787-014-0576-1 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0576-1 Determination of psychosis-related clinical profiles in children with autism spectrum disorders using latent class analysis [Elektronische Daten] [Marinos Kyriakopoulos, Argyris Stringaris, Sofia Manolesou, Maja Radobuljac, Brian Jacobs, Avi Reichenberg, Daniel Stahl, Emily Simonoff, Sophia Frangou] In children with autism spectrum disorders (ASD), high rates of idiosyncratic fears and anxiety reactions and thought disorder are thought to increase the risk of psychosis. The critical next step is to identify whether combinations of these symptoms can be used to categorise individual patients into ASD subclasses, and to test their relevance to psychosis. All patients with ASD (n=84) admitted to a specialist national inpatient unit from 2003 to 2012 were rated for the presence or absence of impairment in affective regulation and anxiety (peculiar phobias, panic episodes, explosive reactions to anxiety), social deficits (social disinterest, avoidance or withdrawal and abnormal attachment) and thought disorder (disorganised or illogical thinking, bizarre fantasies, overvalued or delusional ideas). Latent class analysis of individual symptoms was conducted to identify ASD classes. External validation of these classes was performed using as a criterion the presence of hallucinations. Latent class analysis identified two distinct classes. Bizarre fears and anxiety reactions and thought disorder symptoms differentiated ASD patients into those with psychotic features (ASD-P: 51%) and those without (ASD-NonP: 49%). Hallucinations were present in 26% of the ASD-P class but only 2.4% of the ASD-NonP. Both the ASD-P and the ASD-NonP class benefited from inpatient treatment although inpatient stay was prolonged in the ASD-P class. This study provides the first empirically derived classification of ASD in relation to psychosis based on three underlying symptom dimensions, anxiety, social deficits and thought disorder. These results can be further developed by testing the reproducibility and prognostic value of the identified classes. Springer-Verlag Berlin Heidelberg, 2014 Psychotic symptoms nationallicence MCDD nationallicence Autism spectrum disorder nationallicence Inpatient nationallicence Kyriakopoulos Marinos Child and Adolescent Mental Health Clinical Academic Group, South London and the Maudsley NHS Foundation Trust, London, UK aut Stringaris Argyris Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, P066, De Crespigny Park, SE5 8AF, London, UK aut Manolesou Sofia Central and North West London NHS Foundation Trust, London, UK aut Radobuljac Maja University Psychiatric Hospital, Ljubljana, Slovenia aut Jacobs Brian Child and Adolescent Mental Health Clinical Academic Group, South London and the Maudsley NHS Foundation Trust, London, UK aut Reichenberg Avi Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, P066, De Crespigny Park, SE5 8AF, London, UK aut Stahl Daniel Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, P066, De Crespigny Park, SE5 8AF, London, UK aut Simonoff Emily Child and Adolescent Mental Health Clinical Academic Group, South London and the Maudsley NHS Foundation Trust, London, UK aut Frangou Sophia Icahn School of Medicine at Mount Sinai, New York, USA aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/3(2015-03-01), 301-307 1018-8827 24:3<301 2015 24 787 https://doi.org/10.1007/s00787-014-0576-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0576-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kyriakopoulos Marinos Child and Adolescent Mental Health Clinical Academic Group, South London and the Maudsley NHS Foundation Trust, London, UK aut NATIONALLICENCE 700 1- Stringaris Argyris Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, P066, De Crespigny Park, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Manolesou Sofia Central and North West London NHS Foundation Trust, London, UK aut NATIONALLICENCE 700 1- Radobuljac Maja University Psychiatric Hospital, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Jacobs Brian Child and Adolescent Mental Health Clinical Academic Group, South London and the Maudsley NHS Foundation Trust, London, UK aut NATIONALLICENCE 700 1- Reichenberg Avi Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, P066, De Crespigny Park, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Stahl Daniel Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, P066, De Crespigny Park, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Simonoff Emily Child and Adolescent Mental Health Clinical Academic Group, South London and the Maudsley NHS Foundation Trust, London, UK aut NATIONALLICENCE 700 1- Frangou Sophia Icahn School of Medicine at Mount Sinai, New York, USA aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/3(2015-03-01), 301-307 1018-8827 24:3<301 2015 24 787