Gender effects on brain changes in early-onset psychosis
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| 001 | 605477132 | ||
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| 005 | 20210128100359.0 | ||
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| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00787-014-0669-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00787-014-0669-x | ||
| 245 | 0 | 0 | |a Gender effects on brain changes in early-onset psychosis |h [Elektronische Daten] |c [Marta Rapado-Castro, Cali Bartholomeusz, Josefina Castro-Fornieles, Ana González-Pinto, Soraya Otero, Inmaculada Baeza, Carmen Moreno, Montserrat Graell, Joost Janssen, Nuria Bargalló, Christos Pantelis, Manuel Desco, Celso Arango] |
| 520 | 3 | |a Progressive loss of cortical gray matter (GM) and increase of cerebrospinal fluid (CSF) have been reported in early-onset psychosis (EOP). EOP typically begins during adolescence, a time when developmental brain trajectories differ by gender. This study aimed to determine gender differences in progression of brain changes in this population. A sample of 61 (21 females) adolescents with a first psychotic episode and a matched sample of 70 (23 females) controls underwent both baseline and 2-year follow-up anatomical brain imaging assessments. Regional GM and CSF volumes were obtained using automated methods based on the Talairach's proportional grid system. At baseline, only male patients showed a clear pattern of alterations in the frontal lobe relative to controls (smaller GM and larger CSF volumes). However, parallel longitudinal changes for male and female patients relative to controls were observed, resulting in a common pattern of brain changes across both genders: rate of left frontal lobe GM volume loss was larger in male (−3.8%) and female patients (−4.2%) than in controls (−0.7% males; −0.4% females). The reverse was found for the CSF volume in the left frontal lobe. While the GM and CSF volumes of females with EOP appear to be within the normal range at initial illness onset, our results point to a similar trajectory of increased/accelerated brain changes in both male and female patients with EOP. The pattern of progression of brain changes in psychosis appears to be independent of gender or structural alterations on appearance of psychotic symptoms. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Gender |2 nationallicence | |
| 690 | 7 | |a Psychosis |2 nationallicence | |
| 690 | 7 | |a Adolescent |2 nationallicence | |
| 690 | 7 | |a Brain changes |2 nationallicence | |
| 690 | 7 | |a CAFEPS |2 nationallicence | |
| 690 | 7 | |a MRI |2 nationallicence | |
| 700 | 1 | |a Rapado-Castro |D Marta |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | |
| 700 | 1 | |a Bartholomeusz |D Cali |u Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, 3053, Carlton South, VIC, Australia |4 aut | |
| 700 | 1 | |a Castro-Fornieles |D Josefina |u Child Psychiatry and Psychology Department, Neurosciences Institute, Hospital Clinic de Barcelona, IDIBAPS, SGR-1119, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain |4 aut | |
| 700 | 1 | |a González-Pinto |D Ana |u Hospital Santiago Apóstol de Vitoria, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Kronikgune, EHU-UPV, Vitoria, Spain |4 aut | |
| 700 | 1 | |a Otero |D Soraya |u Child Psychiatry Unit, Hospital Universitario Marqués de Valdecilla, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Santander, Spain |4 aut | |
| 700 | 1 | |a Baeza |D Inmaculada |u Child Psychiatry and Psychology Department, Neurosciences Institute, Hospital Clinic de Barcelona, IDIBAPS, SGR-1119, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain |4 aut | |
| 700 | 1 | |a Moreno |D Carmen |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | |
| 700 | 1 | |a Graell |D Montserrat |u Psychiatry and Psychology Department, Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain |4 aut | |
| 700 | 1 | |a Janssen |D Joost |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | |
| 700 | 1 | |a Bargalló |D Nuria |u Image Diagnostic Center, Hospital Clinic de Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain |4 aut | |
| 700 | 1 | |a Pantelis |D Christos |u Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, 3053, Carlton South, VIC, Australia |4 aut | |
| 700 | 1 | |a Desco |D Manuel |u Department of Bioengineering and Aerospatial Engineering, University Carlos III de Madrid, Madrid, Spain |4 aut | |
| 700 | 1 | |a Arango |D Celso |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | |
| 773 | 0 | |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/10(2015-10-01), 1193-1205 |x 1018-8827 |q 24:10<1193 |1 2015 |2 24 |o 787 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00787-014-0669-x |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00787-014-0669-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rapado-Castro |D Marta |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bartholomeusz |D Cali |u Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, 3053, Carlton South, VIC, Australia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Castro-Fornieles |D Josefina |u Child Psychiatry and Psychology Department, Neurosciences Institute, Hospital Clinic de Barcelona, IDIBAPS, SGR-1119, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a González-Pinto |D Ana |u Hospital Santiago Apóstol de Vitoria, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Kronikgune, EHU-UPV, Vitoria, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Otero |D Soraya |u Child Psychiatry Unit, Hospital Universitario Marqués de Valdecilla, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Santander, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baeza |D Inmaculada |u Child Psychiatry and Psychology Department, Neurosciences Institute, Hospital Clinic de Barcelona, IDIBAPS, SGR-1119, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Moreno |D Carmen |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Graell |D Montserrat |u Psychiatry and Psychology Department, Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Janssen |D Joost |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bargalló |D Nuria |u Image Diagnostic Center, Hospital Clinic de Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pantelis |D Christos |u Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, 3053, Carlton South, VIC, Australia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Desco |D Manuel |u Department of Bioengineering and Aerospatial Engineering, University Carlos III de Madrid, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arango |D Celso |u Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/10(2015-10-01), 1193-1205 |x 1018-8827 |q 24:10<1193 |1 2015 |2 24 |o 787 | ||