caa a22 4500 605477205 CHVBK 20210128100359.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00787-014-0595-y doi (NATIONALLICENCE)springer-10.1007/s00787-014-0595-y Treatment use in a prospective naturalistic cohort of children and adolescents with catatonia [Elektronische Daten] [Marie Raffin, Laetitia Zugaj-Bensaou, Nicolas Bodeau, Vanessa Milhiet, Claudine Laurent, David Cohen, Angèle Consoli] We aimed to (1) describe the treatment used in a large sample of young inpatients with catatonia, (2) determine which factors were associated with improvement and (3) benzodiazepine (BZD) efficacy. From 1993 to 2011, 66 patients between the ages of 9 and 19years were consecutively hospitalized for a catatonic syndrome. We prospectively collected sociodemographic, clinical and treatment data. In total, 51 (77%) patients underwent a BZD trial. BZDs were effective in 33 (65%) patients, who were associated with significantly fewer severe adverse events (p=0.013) and resulted in fewer referrals for electroconvulsive therapy (ECT) (p=0.037). Other treatments included ECT (N=12, 18%); antipsychotic medications, mostly in combination; and treatment of an underlying medical condition, when possible. For 10 patients, four different trials were needed to achieve clinical improvement. When all treatments were combined, there was a better clinical response in acute-onset catatonia (p=0.032). In contrast, the response was lower in boys (p=0.044) and when posturing (p=0.04) and mannerisms (p=0.008) were present as catatonic symptoms. The treatment response was independent of the underlying psychiatric or systemic medical condition. As in adults, BZDs should be the first-line symptomatic treatment for catatonia in young patients, and ECT should be a second option. Additionally, the absence of an association between the response to treatment and the underlying psychiatric condition suggests that catatonia should be considered as a syndrome. Springer-Verlag Berlin Heidelberg, 2014 Catatonia nationallicence Adolescence nationallicence Child nationallicence Pharmacological treatment nationallicence Benzodiazepine nationallicence Electroconvulsive therapy nationallicence Youth nationallicence Raffin Marie Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut Zugaj-Bensaou Laetitia Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut Bodeau Nicolas Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut Milhiet Vanessa Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut Laurent Claudine Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut Cohen David Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut Consoli Angèle Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/4(2015-04-01), 441-449 1018-8827 24:4<441 2015 24 787 https://doi.org/10.1007/s00787-014-0595-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0595-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raffin Marie Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut NATIONALLICENCE 700 1- Zugaj-Bensaou Laetitia Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut NATIONALLICENCE 700 1- Bodeau Nicolas Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut NATIONALLICENCE 700 1- Milhiet Vanessa Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut NATIONALLICENCE 700 1- Laurent Claudine Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut NATIONALLICENCE 700 1- Cohen David Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut NATIONALLICENCE 700 1- Consoli Angèle Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/4(2015-04-01), 441-449 1018-8827 24:4<441 2015 24 787