caa a22 4500 605477221 CHVBK 20210128100359.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00787-014-0586-z doi (NATIONALLICENCE)springer-10.1007/s00787-014-0586-z Measuring quantitative autism traits in families: informant effect or intergenerational transmission? [Elektronische Daten] [Wouter De la Marche, Ilse Noens, Sofie Kuppens, Jantine Spilt, Bart Boets, Jean Steyaert] Autism spectrum disorders (ASD) have a high degree of heritability, but there is still much debate about specific causal genes and pathways. To gain insight into patterns of transmission, research has focused on the relatedness of quantitative autism traits (QAT) between family members, mostly using questionnaires. Yet, different kinds of bias may influence research results. In this paper, we focus on possible informant effects and, taking these into account, on possible intergenerational transmission of QAT. This study used multiple informant data retrieved via the Social Responsiveness Scale from 170 families with at least one member with ASD. Using intraclass correlations (ICCs) and mixed model analyses, we investigated inter-informant agreement and differences between parent and teacher reports on children and between self- and other-reports on adults. Using structural equation modelling (SEM), we investigated the relatedness of QAT between family members in ASD families. Parent-teacher agreement about social responsiveness was poor, especially for children with ASD, though agreement between parents was moderate to strong for affected and unaffected children. Agreement between self- and other-report in adult men was good, but only moderate in women. Agreement did not differ between adults with and without ASD. While accounting for informant effects, our SEM results corroborated the assortative mating theory and the intergenerational transmission of QAT from both fathers and mothers to their offspring. Springer-Verlag Berlin Heidelberg, 2014 Autism spectrum disorders nationallicence Intergenerational transmission nationallicence Assortative mating nationallicence Informant effect nationallicence Informant contrast nationallicence De la Marche Wouter Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut Noens Ilse Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut Kuppens Sofie HIVA - Research Institute for Work and Society, KU Leuven, Leuven, Belgium aut Spilt Jantine School Psychology and Child and Adolescent Development Research Unit, KU Leuven, Leuven, Belgium aut Boets Bart Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut Steyaert Jean Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/4(2015-04-01), 385-395 1018-8827 24:4<385 2015 24 787 https://doi.org/10.1007/s00787-014-0586-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0586-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De la Marche Wouter Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Noens Ilse Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Kuppens Sofie HIVA - Research Institute for Work and Society, KU Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Spilt Jantine School Psychology and Child and Adolescent Development Research Unit, KU Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Boets Bart Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Steyaert Jean Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/4(2015-04-01), 385-395 1018-8827 24:4<385 2015 24 787