caa a22 4500 605477248 CHVBK 20210128100400.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00787-014-0593-0 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0593-0 Predictors of schizophrenia spectrum disorders in early-onset first episodes of psychosis: a support vector machine model [Elektronische Daten] [Laura Pina-Camacho, Juan Garcia-Prieto, Mara Parellada, Josefina Castro-Fornieles, Ana Gonzalez-Pinto, Igor Bombin, Montserrat Graell, Beatriz Paya, Marta Rapado-Castro, Joost Janssen, Inmaculada Baeza, Francisco Pozo, Manuel Desco, Celso Arango] Identifying early-onset schizophrenia spectrum disorders (SSD) at a very early stage remains challenging. To assess the diagnostic predictive value of multiple types of data at the emergence of early-onset first-episode psychosis (FEP), various support vector machine (SVM) classifiers were developed. The data were from a 2-year, prospective, longitudinal study of 81 patients (age 9-17years) with early-onset FEP and a stable diagnosis during follow-up and 42 age- and sex-matched healthy controls (HC). The input was different combinations of baseline clinical, neuropsychological, magnetic resonance imaging brain volumetric and biochemical data, and the output was the diagnosis at follow-up (SSD vs. non-SSD, SSD vs. HC, and non-SSD vs. HC). Enhanced recursive feature elimination was performed for the SSD vs. non-SSD classifier to select and rank the input variables with the highest predictive value for a diagnostic outcome of SSD. After validation with a test set and considering all baseline variables together, the SSD vs. non-SSD, SSD vs. HC and non-SSD vs. HC classifiers achieved an accuracy of 0.81, 0.99 and 0.99, respectively. Regarding the SSD vs. non-SSD classifier, a combination of baseline clinical variables (severity of negative, disorganized symptoms and hallucinations or poor insight) and neuropsychological variables (impaired attention, motor coordination, and global cognition) showed the highest predictive value for a diagnostic outcome of SSD. Neuroimaging and biochemical variables at baseline did not add to the predictive value. Thus, comprehensive clinical/cognitive assessment remains the most reliable approach for differential diagnosis during early-onset FEP. SVMs may constitute promising multivariate tools in the search for predictors of diagnostic outcome in FEP. Springer-Verlag Berlin Heidelberg, 2014 Early-onset psychosis nationallicence Schizophrenia and disorders with psychotic features nationallicence Diagnosis nationallicence Child and adolescent psychiatry nationallicence Support vector machines nationallicence Pina-Camacho Laura Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Garcia-Prieto Juan Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Campus DeMontegancedo, Ctra. M-40, Km. 38, Pozuelo De Alarcón, 28223, Madrid, Spain aut Parellada Mara Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Castro-Fornieles Josefina Child and Adolescent Psychiatry and Psychology Department, Neuroscience Institute, Hospital Clínic, IDIBAPS, SGR-1119, Barcelona, Spain aut Gonzalez-Pinto Ana International Mood Disorders Research Centre. Hospital Santiago Apóstol, Universidad del País Vasco, CIBERSAM, Olaguíbel 29, 01004, Vitoria, Spain aut Bombin Igor Reintegra: Neuro-Rehabilitation Center, Eduardo de Fraga Torrejón 4, 33011, Oviedo, Spain aut Graell Montserrat Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesús, CIBERSAM, Av de Menéndez Pelayo 65, 28009, Madrid, Spain aut Paya Beatriz Child and Adolescent Mental Health Unit, Department of Psychiatry and Psychology, Hospital Universitario Marqués de Valdecilla, CIBERSAM, Av Valdecilla, s/n, 39008, Santander, Spain aut Rapado-Castro Marta Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Janssen Joost Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Baeza Inmaculada Child and Adolescent Psychiatry and Psychology Department, Neuroscience Institute, Hospital Clínic, IDIBAPS, SGR-1119, Barcelona, Spain aut Pozo Francisco Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Campus DeMontegancedo, Ctra. M-40, Km. 38, Pozuelo De Alarcón, 28223, Madrid, Spain aut Desco Manuel Department of Experimental Medicine, Hospital General Universitario Gregorio Marañón. IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut Arango Celso Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/4(2015-04-01), 427-440 1018-8827 24:4<427 2015 24 787 https://doi.org/10.1007/s00787-014-0593-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0593-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pina-Camacho Laura Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Garcia-Prieto Juan Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Campus DeMontegancedo, Ctra. M-40, Km. 38, Pozuelo De Alarcón, 28223, Madrid, Spain aut NATIONALLICENCE 700 1- Parellada Mara Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Castro-Fornieles Josefina Child and Adolescent Psychiatry and Psychology Department, Neuroscience Institute, Hospital Clínic, IDIBAPS, SGR-1119, Barcelona, Spain aut NATIONALLICENCE 700 1- Gonzalez-Pinto Ana International Mood Disorders Research Centre. Hospital Santiago Apóstol, Universidad del País Vasco, CIBERSAM, Olaguíbel 29, 01004, Vitoria, Spain aut NATIONALLICENCE 700 1- Bombin Igor Reintegra: Neuro-Rehabilitation Center, Eduardo de Fraga Torrejón 4, 33011, Oviedo, Spain aut NATIONALLICENCE 700 1- Graell Montserrat Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesús, CIBERSAM, Av de Menéndez Pelayo 65, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Paya Beatriz Child and Adolescent Mental Health Unit, Department of Psychiatry and Psychology, Hospital Universitario Marqués de Valdecilla, CIBERSAM, Av Valdecilla, s/n, 39008, Santander, Spain aut NATIONALLICENCE 700 1- Rapado-Castro Marta Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Janssen Joost Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Baeza Inmaculada Child and Adolescent Psychiatry and Psychology Department, Neuroscience Institute, Hospital Clínic, IDIBAPS, SGR-1119, Barcelona, Spain aut NATIONALLICENCE 700 1- Pozo Francisco Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Campus DeMontegancedo, Ctra. M-40, Km. 38, Pozuelo De Alarcón, 28223, Madrid, Spain aut NATIONALLICENCE 700 1- Desco Manuel Department of Experimental Medicine, Hospital General Universitario Gregorio Marañón. IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 700 1- Arango Celso Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón. School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Ibiza 43, 28009, Madrid, Spain aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/4(2015-04-01), 427-440 1018-8827 24:4<427 2015 24 787