caa a22 4500 605477299 CHVBK 20210128100400.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00787-014-0639-3 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0639-3 Reduced cortical surface area in adolescents with conduct disorder [Elektronische Daten] [Sagari Sarkar, Eileen Daly, Yue Feng, Christine Ecker, Michael Craig, Duncan Harding, Quinton Deeley, Declan Murphy] Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder and psychopathy in adulthood. Neuroimaging research has identified abnormal cortical volume (CV) in CD. However, CV comprises two genetically and developmentally separable components: cortical thickness (CT) and surface area (SA). Aim of this study is to explore the relationship between the cortical constituents of CV in boys with CD. We applied FreeSurfer software to structural MRI data to derive measures of CV, CT, and SA in 21 boys with CD and 19 controls. Relationships between these cortical measures were investigated. Boys with CD had significantly reduced CV and SA compared to non-CD boys in ventromedial and dorsolateral prefrontal cortex. We found no significant between-group differences in CT. Reduced prefrontal CV in boys with CD is associated with significantly reduced SA in the same regions. This finding may help to identify specific neurodevelopmental mechanisms underlying cortical deficits observed in CD. Springer-Verlag Berlin Heidelberg, 2014 Conduct disorder nationallicence Brain anatomy nationallicence Surface based morphometry nationallicence Cortical thickness nationallicence Cortical volume nationallicence Surface area nationallicence Sarkar Sagari Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut Daly Eileen Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut Feng Yue Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut Ecker Christine Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut Craig Michael Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut Harding Duncan Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut Deeley Quinton Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut Murphy Declan Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/8(2015-08-01), 909-917 1018-8827 24:8<909 2015 24 787 https://doi.org/10.1007/s00787-014-0639-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0639-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sarkar Sagari Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Daly Eileen Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Feng Yue Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Ecker Christine Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Craig Michael Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Harding Duncan Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Deeley Quinton Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Murphy Declan Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, SE5 8AF, London, UK aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/8(2015-08-01), 909-917 1018-8827 24:8<909 2015 24 787