Continued cognitive-behavior therapy versus sertraline for children and adolescents with obsessive-compulsive disorder that were non-responders to cognitive-behavior therapy: a randomized controlled trial
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| 024 | 7 | 0 | |a 10.1007/s00787-014-0613-0 |2 doi |
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| 245 | 0 | 0 | |a Continued cognitive-behavior therapy versus sertraline for children and adolescents with obsessive-compulsive disorder that were non-responders to cognitive-behavior therapy: a randomized controlled trial |h [Elektronische Daten] |c [Gudmundur Skarphedinsson, Bernhard Weidle, Per Thomsen, Kitty Dahl, Nor Torp, Judith Nissen, Karin Melin, Katja Hybel, Robert Valderhaug, Tore Wentzel-Larsen, Scott Compton, Tord Ivarsson] |
| 520 | 3 | |a Expert guidelines recommend cognitive-behavior therapy (CBT) as a first-line treatment in pediatric obsessive-compulsive disorder (OCD) and the addition of selective serotonin reuptake inhibitors when CBT is not effective. However, the recommendations for CBT non-responders are not supported by empirical data. Our objective was to investigate the effectiveness of sertraline (SRT) versus continued CBT in children and adolescents that did not respond to an initial course of CBT. Randomized controlled trial conducted in five sites in Denmark, Sweden and Norway, 54 children and adolescents, age 7-17years, with DSM-IV primary OCD were randomized to SRT or continued CBT for 16weeks. These participants had been classified as non-responders to CBT following 14 weekly sessions. Primary outcomes were the CY-BOCS total score and clinical response (CY-BOCS <16). The study was a part of the Nordic Long-Term OCD Treatment Study (NordLOTS). Intent-to-treat sample included 50 participants, mean age 14.0 (SD=2.7) and 48% (n=24) males. Twenty-one of 28 participants (75%) completed continued CBT and 15 of 22 participants (69.2%) completed SRT. Planned pairwise comparison of the CY-BOCS total score did not reveal a significant difference between the treatments (p=.351), the response rate was 50.0% in the CBT group and 45.4% in the SRT group. The multivariate χ 2 test suggested that there were no statistically significant differences between groups (p=.727). Within-group effect sizes were large and significant across both treatments. These large within-group effect sizes suggest that continued treatment for CBT non-responders is beneficial. However, there was no significant between-group differences in SRT or continued CBT at post-treatment. | |
| 540 | |a The Author(s), 2014 | ||
| 690 | 7 | |a Cognitive-behavior therapy |2 nationallicence | |
| 690 | 7 | |a Selective serotonin reuptake inhibitors |2 nationallicence | |
| 690 | 7 | |a Sertraline |2 nationallicence | |
| 690 | 7 | |a Obsessive-compulsive disorder |2 nationallicence | |
| 690 | 7 | |a Children and adolescents |2 nationallicence | |
| 690 | 7 | |a Treatment outcome |2 nationallicence | |
| 700 | 1 | |a Skarphedinsson |D Gudmundur |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | |
| 700 | 1 | |a Weidle |D Bernhard |u Regional Center for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Klostergate 46, 7491, Trondheim, Norway |4 aut | |
| 700 | 1 | |a Thomsen |D Per |u Research Department, Center for Child and Adolescent psychiatry, Aarhus University Hospital, Skovagervej 2, Indgang 81, 0824, Risskov, Denmark |4 aut | |
| 700 | 1 | |a Dahl |D Kitty |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | |
| 700 | 1 | |a Torp |D Nor |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | |
| 700 | 1 | |a Nissen |D Judith |u Research Department, Center for Child and Adolescent psychiatry, Aarhus University Hospital, Skovagervej 2, Indgang 81, 0824, Risskov, Denmark |4 aut | |
| 700 | 1 | |a Melin |D Karin |u Department of Child and Adolescent Psychiatry, BUP Specialmottagning, Queen Silvia's Children's Hospital, Sahlgrenska University Hospital, 41685, Gothenburg, Sweden |4 aut | |
| 700 | 1 | |a Hybel |D Katja |u Research Department, Center for Child and Adolescent psychiatry, Aarhus University Hospital, Skovagervej 2, Indgang 81, 0824, Risskov, Denmark |4 aut | |
| 700 | 1 | |a Valderhaug |D Robert |u Regional Center for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Klostergate 46, 7491, Trondheim, Norway |4 aut | |
| 700 | 1 | |a Wentzel-Larsen |D Tore |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | |
| 700 | 1 | |a Compton |D Scott |u Duke University Medical Center, DUMC 3527, 27710, Durham, NC, USA |4 aut | |
| 700 | 1 | |a Ivarsson |D Tord |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | |
| 773 | 0 | |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/5(2015-05-01), 591-602 |x 1018-8827 |q 24:5<591 |1 2015 |2 24 |o 787 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00787-014-0613-0 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00787-014-0613-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Skarphedinsson |D Gudmundur |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Weidle |D Bernhard |u Regional Center for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Klostergate 46, 7491, Trondheim, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Thomsen |D Per |u Research Department, Center for Child and Adolescent psychiatry, Aarhus University Hospital, Skovagervej 2, Indgang 81, 0824, Risskov, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dahl |D Kitty |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Torp |D Nor |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nissen |D Judith |u Research Department, Center for Child and Adolescent psychiatry, Aarhus University Hospital, Skovagervej 2, Indgang 81, 0824, Risskov, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Melin |D Karin |u Department of Child and Adolescent Psychiatry, BUP Specialmottagning, Queen Silvia's Children's Hospital, Sahlgrenska University Hospital, 41685, Gothenburg, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hybel |D Katja |u Research Department, Center for Child and Adolescent psychiatry, Aarhus University Hospital, Skovagervej 2, Indgang 81, 0824, Risskov, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Valderhaug |D Robert |u Regional Center for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Klostergate 46, 7491, Trondheim, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wentzel-Larsen |D Tore |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Compton |D Scott |u Duke University Medical Center, DUMC 3527, 27710, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ivarsson |D Tord |u Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Gullhaugveien 1-3, 0484, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/5(2015-05-01), 591-602 |x 1018-8827 |q 24:5<591 |1 2015 |2 24 |o 787 | ||